163003 20251009133841.0 doi 10.1007/s10626-025-00419-4 sideral 145538 ART-2025-145538 eng Le Moigne, Manon Probabilistic timed Petri nets for clinical pathway design and analysis: a case study 2025 Access copy available to the general public Unrestricted The COVID-19 pandemic underscored the need for efficient hospital resource management and standardized patient care. Clinical pathways, structured plans for managing specific conditions, are critical but challenging to design and update. This paper introduces a methodology combining pattern mining and Probabilistic Timed Petri Nets (PTPN) to model, simulate, and evaluate clinical pathways, incorporating probabilistic transitions and continuous-time distributions for activity durations. In collaboration with medical professionals, the proposed methodology has been successfully applied to develop a clinical pathway for anterior cruciate ligament (ACL) ruptures using real data. Iterative refinement addressed data inconsistencies, producing a robust PTPN model that optimizes patient care and resource allocation. Validation using the CASAS database demonstrate the adaptability of the method to different healthcare contexts. info:eu-repo/grantAgreement/EUR/AEI/TED2021-130449B-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2020-113969RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2021-125514NB-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mahulea, Cristian Universidad de Zaragoza (orcid)0000-0003-0056-2225 Faraut, Gregory Bernardi, Simona Universidad de Zaragoza (orcid)0000-0002-2605-6243 Albareda, Jorge (orcid)0000-0003-4489-3130 Castán, Lidia 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5007 570 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Lenguajes y Sistemas Inf. 35, 3 (2025), 205-231 Discret. event dyn. syst. DISCRETE EVENT DYNAMIC SYSTEMS-THEORY AND APPLICATIONS 0924-6703 3116971 http://zaguan.unizar.es/record/163003/files/texto_completo.pdf Versión publicada 1360540 http://zaguan.unizar.es/record/163003/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:163003 articulos driver 2025-10-09-13:25:56 ARTICLE