000163009 001__ 163009
000163009 005__ 20251009133841.0
000163009 0247_ $$2doi$$a10.1007/s11357-025-01784-6
000163009 0248_ $$2sideral$$a145586
000163009 037__ $$aART-2025-145586
000163009 041__ $$aeng
000163009 100__ $$aHernández-Bellido, Natalia
000163009 245__ $$aA simple blood biomarker based on gene expression describes cardiovascular health-related biological age
000163009 260__ $$c2025
000163009 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163009 5203_ $$aAbstract
The need to monitor the aging process as a risk factor for disease and mortality beyond chronological age (CA) has led to numerous investigations into the estimation of the biological age (BA) of individuals. However, the accuracy of BA estimation tools is often judged by their ability to approximate CA, questioning their value in capturing the variance in health status and thus correctly estimating BA. Their biological relevance is often assessed in relation to health outcomes or mortality, underexploiting their potential for real-time monitoring of BA. Furthermore, their complexity may limit their clinical translation to large populations. Here, we describe the gene expression-based age monitoring Clock (GamC), a simple biomarker of aging (BOA), and characterize its biological relevance with synchronous cardiovascular (CV) health-related functional data. GamC is calculated from the expression levels of three genes consistently dysregulated with age in blood (ABLIM1, CCR7, and LEF1). GamC shows moderate but reliable association with CA in three independent cohorts, supported by transcriptome-wide changes. It demonstrates specialized biological meaning, as it specifically describes current physical activity levels, but poorly correlates with autonomic nervous system function, both age-related factors associated with CV health. Finally, it expresses BA monitoring capacity by modestly responding to an effective exercise-based intervention in centenarians. In conclusion, GamC is proposed as a simple and affordable candidate BOA for reporting the individuals’ current CV health-related BA, thus promoting its broad translation and application into measures aimed at promoting healthy aging in relation to CV health, the leading cause of death worldwide.
000163009 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-24R$$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/ES/MCINN/PID2022-139859OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000163009 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163009 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163009 700__ $$0(orcid)0000-0001-6025-5070$$aHernández-Vicente, Adrián$$uUniversidad de Zaragoza
000163009 700__ $$0(orcid)0000-0002-2954-1068$$aGarcía-Mendívil, Laura$$uUniversidad de Zaragoza
000163009 700__ $$0(orcid)0000-0002-9218-6062$$aRamos-Marquès, Estel
000163009 700__ $$0(orcid)0000-0002-1462-4880$$aHernando, David$$uUniversidad de Zaragoza
000163009 700__ $$0(orcid)0000-0002-3312-7759$$aCebollada, Alberto
000163009 700__ $$0(orcid)0000-0002-0833-9717$$aKöhler, Ralf
000163009 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza
000163009 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000163009 700__ $$0(orcid)0000-0003-3982-1263$$aOrdovás, Laura
000163009 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000163009 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000163009 773__ $$g(2025), 17 pp.$$pGeroScience$$tGeroScience$$x2509-2715
000163009 8564_ $$s3205138$$uhttps://zaguan.unizar.es/record/163009/files/texto_completo.pdf$$yVersión publicada
000163009 8564_ $$s1851407$$uhttps://zaguan.unizar.es/record/163009/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163009 909CO $$ooai:zaguan.unizar.es:163009$$particulos$$pdriver
000163009 951__ $$a2025-10-09-13:25:56
000163009 980__ $$aARTICLE