000163036 001__ 163036
000163036 005__ 20251009133839.0
000163036 0247_ $$2doi$$a10.1016/j.biomaterials.2022.121453
000163036 0248_ $$2sideral$$a128455
000163036 037__ $$aART-2022-128455
000163036 041__ $$aeng
000163036 100__ $$0(orcid)0000-0002-2576-6382$$aPrieto, Martin
000163036 245__ $$aLight activated pulsatile drug delivery for prolonged peripheral nerve block
000163036 260__ $$c2022
000163036 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163036 5203_ $$aRegional anesthesia is widely used in peripheral nerve block and in neuraxial anesthesia to reduce anesthetics systemic side effects and shorten recovery times. However, when applied as a single injection (e.g., peripheral nerve block) it is limited by the duration of its effect. Herein, we develop a thermoresponsive nanogel based on poly(oligoethylene glycol methacrylate) containing the long-lasting anesthetic bupivacaine, which can be externally activated by using near-infrared light due to the photothermal properties of hollow gold nanoparticles embedded in the nanogel which facilitate its phase transition, triggering drug release at a controlled temperature above body temperature. Bupivacaine in vitro release can be repeatedly triggered to achieve a controlled pulsatile release of the drug due to the reversible nature of the thermosensitive nanogel, achieving a spatio-temporal control of the release. In vivo sciatic nerve block demonstrates that whereas the administered dose of free bupivacaine produces sensory block and impaired motor function for 2 h, the equivalent bupivacaine dose included in the developed release system can significantly prolong its neurobehavioral anesthetic effect for over 6 h. This release system can also be reactivated multiple times by subsequent irradiation cycles without observing detrimental toxicity in the infiltrated tissues. © 2022 Elsevier Ltd
000163036 536__ $$9info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715$$9info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092$$9info:eu-repo/grantAgreement/ES/MCINN/PRE2018-085769$$9info:eu-repo/grantAgreement/ES/MICINN BES-2015-073735
000163036 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000163036 590__ $$a14.0$$b2022
000163036 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b2 / 45 = 0.044$$c2022$$dQ1$$eT1
000163036 591__ $$aENGINEERING, BIOMEDICAL$$b4 / 96 = 0.042$$c2022$$dQ1$$eT1
000163036 592__ $$a2.716$$b2022
000163036 593__ $$aBioengineering$$c2022$$dQ1
000163036 593__ $$aBiomaterials$$c2022$$dQ1
000163036 593__ $$aNanoscience and Nanotechnology$$c2022$$dQ1
000163036 593__ $$aCeramics and Composites$$c2022$$dQ1
000163036 593__ $$aMechanics of Materials$$c2022$$dQ1
000163036 593__ $$aBiophysics$$c2022$$dQ1
000163036 594__ $$a23.4$$b2022
000163036 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000163036 700__ $$0(orcid)0000-0002-4678-7465$$aUsón, Laura
000163036 700__ $$0(orcid)0000-0002-0595-5514$$aGarcía-Salinas, Sara
000163036 700__ $$0(orcid)0000-0002-1505-498X$$aYus, Cristina$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0003-1599-8216$$aLanda, Guillermo$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0002-9324-0446$$aAlejo, Teresa$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0002-2053-9842$$aLujan, Lluis$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0001-8572-1760$$aPérez, Marta$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, Silvia$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000163036 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000163036 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000163036 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000163036 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000163036 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000163036 773__ $$g283 (2022), 121453 [16 pp.]$$pBiomaterials$$tBiomaterials$$x0142-9612
000163036 8564_ $$s7313288$$uhttps://zaguan.unizar.es/record/163036/files/texto_completo.pdf$$yPostprint
000163036 8564_ $$s1012828$$uhttps://zaguan.unizar.es/record/163036/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000163036 909CO $$ooai:zaguan.unizar.es:163036$$particulos$$pdriver
000163036 951__ $$a2025-10-09-13:25:43
000163036 980__ $$aARTICLE