163036 20251009133839.0 doi 10.1016/j.biomaterials.2022.121453 sideral 128455 ART-2022-128455 eng Prieto, Martin (orcid)0000-0002-2576-6382 Light activated pulsatile drug delivery for prolonged peripheral nerve block 2022 Access copy available to the general public Unrestricted Regional anesthesia is widely used in peripheral nerve block and in neuraxial anesthesia to reduce anesthetics systemic side effects and shorten recovery times. However, when applied as a single injection (e.g., peripheral nerve block) it is limited by the duration of its effect. Herein, we develop a thermoresponsive nanogel based on poly(oligoethylene glycol methacrylate) containing the long-lasting anesthetic bupivacaine, which can be externally activated by using near-infrared light due to the photothermal properties of hollow gold nanoparticles embedded in the nanogel which facilitate its phase transition, triggering drug release at a controlled temperature above body temperature. Bupivacaine in vitro release can be repeatedly triggered to achieve a controlled pulsatile release of the drug due to the reversible nature of the thermosensitive nanogel, achieving a spatio-temporal control of the release. In vivo sciatic nerve block demonstrates that whereas the administered dose of free bupivacaine produces sensory block and impaired motor function for 2 h, the equivalent bupivacaine dose included in the developed release system can significantly prolong its neurobehavioral anesthetic effect for over 6 h. This release system can also be reactivated multiple times by subsequent irradiation cycles without observing detrimental toxicity in the infiltrated tissues. © 2022 Elsevier Ltd info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715 info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092 info:eu-repo/grantAgreement/ES/MCINN/PRE2018-085769 info:eu-repo/grantAgreement/ES/MICINN BES-2015-073735 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 14.0 2022 MATERIALS SCIENCE, BIOMATERIALS 2 / 45 = 0.044 2022 Q1 T1 ENGINEERING, BIOMEDICAL 4 / 96 = 0.042 2022 Q1 T1 2.716 2022 Bioengineering 2022 Q1 Biomaterials 2022 Q1 Nanoscience and Nanotechnology 2022 Q1 Ceramics and Composites 2022 Q1 Mechanics of Materials 2022 Q1 Biophysics 2022 Q1 23.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Usón, Laura (orcid)0000-0002-4678-7465 García-Salinas, Sara (orcid)0000-0002-0595-5514 Yus, Cristina Universidad de Zaragoza (orcid)0000-0002-1505-498X Landa, Guillermo Universidad de Zaragoza (orcid)0000-0003-1599-8216 Alejo, Teresa Universidad de Zaragoza (orcid)0000-0002-9324-0446 Lujan, Lluis Universidad de Zaragoza (orcid)0000-0002-2053-9842 Pérez, Marta Universidad de Zaragoza (orcid)0000-0001-8572-1760 Irusta, Silvia Universidad de Zaragoza (orcid)0000-0002-2966-9088 Sebastian, Victor Universidad de Zaragoza (orcid)0000-0002-6873-5244 Mendoza, Gracia (orcid)0000-0003-2293-363X Arruebo, Manuel Universidad de Zaragoza (orcid)0000-0003-3165-0156 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 283 (2022), 121453 [16 pp.] Biomaterials Biomaterials 0142-9612 7313288 http://zaguan.unizar.es/record/163036/files/texto_completo.pdf Postprint 1012828 http://zaguan.unizar.es/record/163036/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:163036 articulos driver 2025-10-09-13:25:43 ARTICLE