doi:10.1016/j.rineng.2025.107376engVelarte, AntonioSannino, AndreaOtin, AranzazuSantamaría, BeatrizArtigas, José IgnacioPueyo, EstherOptical fiber integration in PDMS devices for dynamic tissue deformationART-2025-145544This study introduces an advanced optical fiber-based stretchable sensing platform designed for precise biomechanical characterization in tissue engineering applications, specifically tailored for cardiac tissue studies. The system is entirely fabricated from biocompatible polydimethylsiloxane (PDMS) material, and features a thin upper membrane and an internal cavity where controlled pneumatic deformation occurs. Deformation is quantified through changes in optical intensity measured through a strategically aligned optical fiber pair, as membrane stretching disrupts total internal reflection conditions. Finite element modeling using COMSOL is used to optimize device geometry and predict deformation, which is subsequently validated through experimental analyses. A custom-designed electronic system with capacity for real-time signal processing ensures stable and sensitive data acquisition. The experimental results show high levels of linearity and repeatability in a physiologically relevant stretch range, highlighting its potential for biomechanical research applications and dynamic tissue stimulation. Future improvements are directed toward extending the reliable deformation operating range through advances in the optical system.2025http://zaguan.unizar.es/record/16304610.1016/j.rineng.2025.107376http://zaguan.unizar.es/record/163046oai:zaguan.unizar.es:163046info:eu-repo/grantAgreement/ES/DGA/GEPM T23-23info:eu-repo/grantAgreement/ES/DGA/LMP94_21info:eu-repo/grantAgreement/ES/DGA/T39-23Rinfo:eu-repo/grantAgreement/ES/ISCIII/PT23-00167info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00info:eu-repo/grantAgreement/ES/MICINN/PID2023-149403NB-I00info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00Results in Engineering 28 (2025), 107376 [10 pp.]by-nchttps://creativecommons.org/licenses/by-nc/4.0/deed.esinfo:eu-repo/semantics/openAccess