000163070 001__ 163070
000163070 005__ 20251009133841.0
000163070 0247_ $$2doi$$a10.1002/anbr.202500118
000163070 0248_ $$2sideral$$a145532
000163070 037__ $$aART-2025-145532
000163070 041__ $$aeng
000163070 100__ $$aMcGuigan, Aisling
000163070 245__ $$aIn‐Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors
000163070 260__ $$c2025
000163070 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163070 5203_ $$aIn the quest to alleviate the severe side effects of chemotherapy, a promising approach is through prodrugs, an inactivate form of the drug that is administered systemically but activated locally. Bioorthogonal chemistry has the potential to generate high doses of drug at the tumor site with minimal off‐target exposure. To harness the potential of bioorthogonal prodrugs, implantable heterogenous catalysts consisting of biocompatible polymers with immobilized metal nanoparticles are required. Polymers based on poly(2‐hydroxyethyl methacrylate) with different levels of hydrophilicity are functionalized with either palladium nanocubes (≈10 nm) or palladium nanosheets (<200 nm). Using a palladium‐sensitive fluorogenic model compound, propargylated resorufin, the nanosheets show higher catalytic activity than the nanocubes, as well as better metal retainment within the hydrogels. The more hydrophilic polymers show improved diffusion, conversion, and release and better recyclability. Converted product is sequestered by the polymer and released with delay, establishing a potential route to sustained release. These heterogenous catalysts can facilitate the clinical translation of bioorthogonal prodrugs.
000163070 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163070 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163070 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000163070 700__ $$aUnciti-Broceta, Asier
000163070 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000163070 700__ $$aMelchels, Ferry
000163070 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000163070 773__ $$g(2025), 2500118 [11 pp.]$$tAdvanced nanoBiomed research$$x2699-9307
000163070 8564_ $$s1437096$$uhttps://zaguan.unizar.es/record/163070/files/texto_completo.pdf$$yVersión publicada
000163070 8564_ $$s2431621$$uhttps://zaguan.unizar.es/record/163070/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163070 909CO $$ooai:zaguan.unizar.es:163070$$particulos$$pdriver
000163070 951__ $$a2025-10-09-13:25:56
000163070 980__ $$aARTICLE