000163147 001__ 163147
000163147 005__ 20251009145936.0
000163147 0247_ $$2doi$$a10.1126/sciadv.adz5524
000163147 0248_ $$2sideral$$a145631
000163147 037__ $$aART-2025-145631
000163147 041__ $$aeng
000163147 100__ $$aPascual-Valdunciel, Alejandro$$uUniversidad de Zaragoza
000163147 245__ $$aPersonalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling
000163147 260__ $$c2025
000163147 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163147 5203_ $$aStudying human motoneuron activity through electromyography (EMG) can yield insights into the operation of fundamental spinal cord microcircuits. Traditional surface and needle EMG methodologies have limited capacity to shed light on the diversity of motor unit (MU) control strategies that may be unique to each individual. Here, we used high-density surface EMG (HDsEMG) to sample multiple MUs per participant to investigate the features of inhibitory spinal microcircuits in both upper and lower limb control. We characterized the net inhibition as a function of individual MU firing rates, revealing participant-specific relationships. In silico modeling replicated these experimental characteristics and suggested that properties of the inhibitory currents rather than motoneuron size are responsible for net functional inhibition. Our results show that HDsEMG can highlight distinct control strategies across circuits and motor pools, revealing participant-specific properties of inhibitory spinal microcircuits.
000163147 536__ $$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101151398/EU/Implementation and validation of a closed-loop neural interface to entrain brain rhythms and reduce motor symptoms in Parkinson’s Disease
000163147 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163147 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163147 700__ $$aCónsul, Natalia T.
000163147 700__ $$aBrownstone, Robert M.
000163147 700__ $$aBeato, Marco
000163147 700__ $$aFarina, Dario
000163147 700__ $$aNascimento, Filipe
000163147 700__ $$aÖzyurt, M. Görkem
000163147 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000163147 773__ $$g11 (2025), eadz5524 [18 pp.]$$pSci. adv.$$tScience advances$$x2375-2548
000163147 787__ $$tPersonalized mapping of inhibitory spinal cord circuits in humans via non-invasive neural decoding and in silico modelling$$whttps://zenodo.org/records/16740503
000163147 8564_ $$s2662314$$uhttps://zaguan.unizar.es/record/163147/files/texto_completo.pdf$$yVersión publicada
000163147 8564_ $$s3668545$$uhttps://zaguan.unizar.es/record/163147/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163147 909CO $$ooai:zaguan.unizar.es:163147$$particulos$$pdriver
000163147 951__ $$a2025-10-08-13:00:10
000163147 980__ $$aARTICLE