Identification of plasma protein mediators of blood pressure and cardiovascular disease: what are the next steps?

Munroe, Patricia B ; Young, William J ; Ramírez, Julia (Universidad de Zaragoza)

Resumen: Background: There are strong epidemiological data demonstrating an association between blood pressure (BP) and increased risk of cardiovascular events including coronary artery disease (CAD) and stroke. Over recent years, genome-wide association studies (GWAS) have been performed separately for each trait, with many discovered loci, and BP polygenic risk scores have demonstrated significant associations with both cardiovascular outcomes. Pleiotropic genetic variants (the same variant associated with more than one phenotype) have also been reported across BP, CAD, and stroke. With the advent of high-throughput protein profiling assays, researchers are now linking genetic associations to protein expression as a next step in the discovery of effector proteins and disease mechanisms. The study by Meena et al. published in this issue of the European Heart Journal explores whether there is a set of shared plasma proteins between BP, CAD, and stroke that influence cardiovascular risk by their effects on BP using a Mendelian randomization (MR) framework and co- localization analyses...

Idioma: Inglés

DOI: 10.1093/eurheartj/ehaf530

Año: 2025

Publicado en: European heart journal (2025), [3 pp.]
ISSN: 0195-668X

Tipo y forma: (PostPrint)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)