000163272 001__ 163272
000163272 005__ 20251024172258.0
000163272 0247_ $$2doi$$a10.1038/s41746-025-01990-8
000163272 0248_ $$2sideral$$a145740
000163272 037__ $$aART-2025-145740
000163272 041__ $$aeng
000163272 100__ $$aZarski, Anna-Carlotta
000163272 245__ $$aInternet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial
000163272 260__ $$c2025
000163272 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163272 5203_ $$aPreventing mental disorders is important to avoiding clinical conditions. This study evaluated the efficacy of internet-based indicated prevention for anxiety and depressive disorders. In a three-arm randomized controlled trial, 566 adults with subthreshold anxiety (GAD-7 ≥ 5) and/or depressive symptoms (CES-D ≥ 16), but no clinical diagnosis in the past six months (MINI 6.0), were assigned to either an individually (IG-IMI, n = 186) or automatically (AG-IMI, n = 189) guided digital intervention, or waitlist control (WLC, n = 191). The digital intervention comprised 8 transdiagnostic, self-tailored, CBT-based sessions. The primary outcome was time to onset of any anxiety or depressive disorder over 12 months, assessed via blinded diagnostic interviews (MINI). AD/DD onset was 19.4% in IG-IMI, 14.8% in AG-IMI, and 30.9% in WLC. Cumulative incidence was 23.1% (IG-IMI), 20.7% (AG-IMI), and 36.0% (WLC; p < 0.001). Hazard ratios were 0.59 and 0.47; NNTs were 7.76 and 5.79. Both individually guided and automated interventions effectively reduced AD/DD incidence. Trial Registration: The study was preregistered in the German Clinical Trial Registration (DRKS00011099;https://drks.de/search/de/trial/DRKS00011099).
000163272 536__ $$9info:eu-repo/grantAgreement/EC/H2020/634757/EU/Integrating Technology into Mental Health Care Delivery in Europe/ICare$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 634757-ICare
000163272 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163272 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163272 700__ $$aWeisel, Kiona K.
000163272 700__ $$aBerger, Thomas
000163272 700__ $$aKrieger, Tobias
000163272 700__ $$aSchaub, Michael P.
000163272 700__ $$aBerking, Matthias
000163272 700__ $$aGörlich, Dennis
000163272 700__ $$aJacobi, Corinna
000163272 700__ $$aBaños, Rosa
000163272 700__ $$aBotella, Cristina
000163272 700__ $$0(orcid)0000-0001-6987-6607$$aHerrero, Rocio$$uUniversidad de Zaragoza
000163272 700__ $$aEbert, David D.
000163272 7102_ $$14009$$2680$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Person.Eval.Trat.Psicoló.
000163272 773__ $$g8, 589 (2025), 7$$pnpj digit. med.$$tnpj digital medicine$$x2398-6352
000163272 8564_ $$s787936$$uhttps://zaguan.unizar.es/record/163272/files/texto_completo.pdf$$yVersión publicada
000163272 8564_ $$s2824716$$uhttps://zaguan.unizar.es/record/163272/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163272 909CO $$ooai:zaguan.unizar.es:163272$$particulos$$pdriver
000163272 951__ $$a2025-10-24-16:56:14
000163272 980__ $$aARTICLE