000163325 001__ 163325
000163325 005__ 20251024172259.0
000163325 0247_ $$2doi$$a10.3389/fdgth.2025.1637195
000163325 0248_ $$2sideral$$a145761
000163325 037__ $$aART-2025-145761
000163325 041__ $$aeng
000163325 100__ $$aDaghir-Wojtkowiak, Emilia
000163325 245__ $$aLeveraging knowledge for explainable AI in personalized cancer treatment: challenges and future directions
000163325 260__ $$c2025
000163325 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163325 5203_ $$aIntegrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based AI-driven decision-support system continuously maintained and updated to align with the latest clinical guidelines. A key challenge to ensure its real-life adoption lies in translating the outcomes of complex AI-driven data integration and modeling into a form easily understood by the clinical audience. To ensure explainability, knowledge graphs have emerged as data models integrating multi-omics data sources and representing them as interconnected networks. Knowledge graphs offer a framework which AI models can progressively refine, highlighting the most influential features and relationships facilitating transparency of complex interactions and interdependencies. In this perspective we present major components and challenges upon developing a knowledge-based explainable AI system. Additionally, we showcase a current effort undertaken by the Knowledge at the Tips of your Fingers (KATY) consortium to develop the infrastructure for an explainable system supporting best treatment decision for a renal cancer patient.
000163325 536__ $$9info:eu-repo/grantAgreement/EC/H2020/101017453/EU/Knowledge At the Tip of Your fingers: Clinical Knowledge for Humanity/KATY$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101017453-KATY
000163325 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163325 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163325 700__ $$aAlfaro, Javier
000163325 700__ $$aMastromattei, Michele
000163325 700__ $$aPalkowski, Aleksander
000163325 700__ $$aStares, Mark
000163325 700__ $$aRoca-Umbert, Ana
000163325 700__ $$aKrajnc, Andraz
000163325 700__ $$aLeoni, Riccardo
000163325 700__ $$aBoland, Anne
000163325 700__ $$aNourbaksh, Aria
000163325 700__ $$aKallor, Ashwin
000163325 700__ $$aDucki, Camille
000163325 700__ $$aVenditti, Davide
000163325 700__ $$aMontesano, Carla
000163325 700__ $$aCipriani, Chiara
000163325 700__ $$aFaria, Daniel
000163325 700__ $$aPflieger, Delphine
000163325 700__ $$aZago, Elisa
000163325 700__ $$aBardet, Etienne
000163325 700__ $$aSerrano, Filipa
000163325 700__ $$aJeanneret, Florian
000163325 700__ $$aAlouges, Damien
000163325 700__ $$aYin, Liangwei
000163325 700__ $$aCoquelet, Elodine
000163325 700__ $$aBacquet, Apolline
000163325 700__ $$aBonchi, Francesco
000163325 700__ $$aMaiorino, Francesco
000163325 700__ $$aTorino, Francesco
000163325 700__ $$aBedran, Georges
000163325 700__ $$aLong, Jean-Alexandre
000163325 700__ $$aBalbi, Laura
000163325 700__ $$aGuyon, Laurent
000163325 700__ $$aBevilacqua, Liana
000163325 700__ $$aFiorelli, Manuel
000163325 700__ $$aWagner, Marie-Catherine
000163325 700__ $$aReyes, Mario
000163325 700__ $$aRoselli, Mario
000163325 700__ $$aSilva, Marta Contreiras
000163325 700__ $$aWaleron, Michal
000163325 700__ $$aDovrolis, Nikolas
000163325 700__ $$aFilhol-Cochet, Odile
000163325 700__ $$aUm, In Hwa
000163325 700__ $$aWolflein, Georg
000163325 700__ $$aEugénio, Patrícia
000163325 700__ $$aBazelle, Pauline
000163325 700__ $$aGolnas, Pavlos
000163325 700__ $$aThorpe, Peter
000163325 700__ $$aBove, Pierluigi
000163325 700__ $$aBorole, Piyush
000163325 700__ $$aBernardini, Roberta
000163325 700__ $$aKumar, Rohit
000163325 700__ $$aCicconi, Rosella
000163325 700__ $$aKaltenbrunner, Saskia
000163325 700__ $$aGravina, Saverio
000163325 700__ $$aBrezar, Simona
000163325 700__ $$aSymeonides, Stefan
000163325 700__ $$aMcGinn, Steven
000163325 700__ $$aNunes, Susana
000163325 700__ $$aHupp, Ted
000163325 700__ $$aGordienko, Yuri
000163325 700__ $$aVarvaras, Dimitrios
000163325 700__ $$aStirenko, Sergii
000163325 700__ $$aXumerle, Luciano
000163325 700__ $$aMariani, Stefania
000163325 700__ $$aBouzit, Assilah
000163325 700__ $$aGazut, Stéphane
000163325 700__ $$aPoth, Heiko
000163325 700__ $$aSouliotis, Kyriakos
000163325 700__ $$aKatifelis, Hector
000163325 700__ $$aVerzoni, Elena
000163325 700__ $$aProcopio, Giuseppe
000163325 700__ $$aSchoch, Sarah
000163325 700__ $$aLupiáñez-Villanueva, Francisco
000163325 700__ $$aTürk, Sandra
000163325 700__ $$aBarud, Katarzyna
000163325 700__ $$aKoroliouk, Dimitri
000163325 700__ $$aCaubet, Juan
000163325 700__ $$0(orcid)0000-0002-0895-1893$$aMoreno, Yamir$$uUniversidad de Zaragoza
000163325 700__ $$aDescotes, Jean-Luc
000163325 700__ $$aGolna, Christina
000163325 700__ $$aGuadalupi, Valentina
000163325 700__ $$aGaragnani, Paolo
000163325 700__ $$aGazouli, Maria
000163325 700__ $$aDeleuze, Jean-François
000163325 700__ $$aFolkvord, Frans
000163325 700__ $$aForgó, Nikolaus
000163325 700__ $$aHarrison, David J.
000163325 700__ $$aAxelson, Håkan
000163325 700__ $$aStellato, Armando
000163325 700__ $$aMattei, Maurizio
000163325 700__ $$aRajan, Ajitha
000163325 700__ $$aLaird, Alexander
000163325 700__ $$aBattail, Christophe
000163325 700__ $$aPesquita, Catia
000163325 700__ $$aZanzotto, Fabio Massimo
000163325 7102_ $$12004$$2405$$aUniversidad de Zaragoza$$bDpto. Física Teórica$$cÁrea Física Teórica
000163325 773__ $$g7 (2025), [10 pp.]$$tFrontiers in digital health$$x2673-253X
000163325 8564_ $$s645194$$uhttps://zaguan.unizar.es/record/163325/files/texto_completo.pdf$$yVersión publicada
000163325 8564_ $$s2350846$$uhttps://zaguan.unizar.es/record/163325/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163325 909CO $$ooai:zaguan.unizar.es:163325$$particulos$$pdriver
000163325 951__ $$a2025-10-24-16:57:09
000163325 980__ $$aARTICLE