000163714 001__ 163714
000163714 005__ 20251030150826.0
000163714 0247_ $$2doi$$a10.1002/ehf2.15380
000163714 0248_ $$2sideral$$a145794
000163714 037__ $$aART-2025-145794
000163714 041__ $$aeng
000163714 100__ $$0(orcid)0000-0002-8328-9836$$aJosa-Laorden, C.
000163714 245__ $$aThe role of intra‐abdominal pressure and point of care ultrasound to guide decongestive therapies in acute heart failure
000163714 260__ $$c2025
000163714 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163714 5203_ $$aAims: Effective decongestion is crucial in managing acute decompensated heart failure (ADHF). Persistent congestion post‐diuretic therapy correlates with adverse outcomes. This study evaluates whether a strategy guided by intra‐abdominal pressure (IAP) and point‐of‐care ultrasound (POCUS) enhances decongestion compared to standard diuretic titration.
Methods and results: ABDOPOCUS‐HF is a randomized, multicentre, open‐label, pragmatic clinical trial involving 168 patients hospitalized with ADHF across 14 Spanish hospitals. Inclusion criteria encompass clinical signs of congestion and elevated natriuretic peptides (NT‐proBNP >1000 pg/mL or BNP > 250 pg/mL). Participants are randomized 1:1 to either standard care or an intervention arm where diuretic therapy is guided by baseline IAP measurements and POCUS assessments, including lung ultrasound, inferior vena cava diameter and VExUS score. The primary endpoint is the resolution of systemic congestion at 72 h, measured by the ADVOR score. Secondary endpoints include changes in pulmonary congestion (B‐lines), intravascular congestion (VExUS and IVC), biomarkers (NT‐proBNP and CA125), total diuretic dose, diuretic response, hospital length of stay and rates of cardiovascular death, rehospitalization and need for intravenous diuretics at 30 and 90 days. Safety endpoints encompass worsening renal function, electrolyte disturbances and catheter‐related infections.
Conclusions: The ABDOPOCUS‐HF trial investigates whether integrating IAP and POCUS into decongestion strategies improves diuretic response and clinical outcomes in ADHF patients. Findings may inform future protocols for volume management in acute heart failure.
000163714 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00797
000163714 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000163714 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163714 700__ $$aCampos-Saenz de Santamaría, A.$$uUniversidad de Zaragoza
000163714 700__ $$aCrespo-Aznarez, S.
000163714 700__ $$aPérez-Silvestre, J.
000163714 700__ $$aMontero-Hernandez, E.
000163714 700__ $$aLlacer-Iborra, P.
000163714 700__ $$aTorres-Macho, J.
000163714 700__ $$aMéndez-Bailon, M.
000163714 700__ $$aMorales-Rull, J.L.
000163714 700__ $$aSalamanca-Bautista, P.
000163714 700__ $$aFernández-Villa, N.
000163714 700__ $$aTorres-Courchoud, I.
000163714 700__ $$aVázquez-Ronda, M.A.
000163714 700__ $$aMartínez-Gutiérrez, R.
000163714 700__ $$aSerrano-Irigoyen, P.
000163714 700__ $$aGarcía-Lorente, N.
000163714 700__ $$aTrullas, J.C.
000163714 700__ $$aCobo-Marcos, M.
000163714 700__ $$aPinilla, M.J.$$uUniversidad de Zaragoza
000163714 700__ $$0(orcid)0000-0002-2338-7637$$aSánchez-Marteles, M.$$uUniversidad de Zaragoza
000163714 700__ $$0(orcid)0000-0002-4769-7154$$aRubio-Gracia, J.$$uUniversidad de Zaragoza
000163714 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000163714 773__ $$g12, 5 (2025), 3741-3749$$tESC heart failure$$x2055-5822
000163714 8564_ $$s1002431$$uhttps://zaguan.unizar.es/record/163714/files/texto_completo.pdf$$yVersión publicada
000163714 8564_ $$s2341857$$uhttps://zaguan.unizar.es/record/163714/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163714 909CO $$ooai:zaguan.unizar.es:163714$$particulos$$pdriver
000163714 951__ $$a2025-10-30-14:39:32
000163714 980__ $$aARTICLE