000163793 001__ 163793
000163793 005__ 20251107115328.0
000163793 0247_ $$2doi$$a10.1038/s41467-025-63756-w
000163793 0248_ $$2sideral$$a145856
000163793 037__ $$aART-2025-145856
000163793 041__ $$aeng
000163793 100__ $$aJaroentomeechai, Thapakorn
000163793 245__ $$aMicrobial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins
000163793 260__ $$c2025
000163793 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163793 5203_ $$aThe mucus lining wet body surfaces forms the interphase and barrier for the microbiota and resident microbiomes. Large mucin proteins densely decorated with O-glycans make up the mucus lining to entrap, feed and shape the microbiota, and repress biofilm formation and virulence. How mucins exert these effects is poorly understood and critical is how the microbiota recognize, sense, and break down mucins. Here, we provide structural molecular evidence that a small mucin-binding module designated X409 recognizes clustered saccharide patches comprised of rows of inner monosaccharides in adjacent O-glycans. These patches are unique to mucins and binding to these provides an elegant mechanism to retain adherence to mucins despite trimming of O-glycans during microbial scavenging of monosaccharides from mucins. Realization of clustered saccharide patch-binding motifs provides a hitherto overlooked scenario of contextual glycan epitopes and impetus for discovery of new classes of glycan-binding proteins.
000163793 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E34-R17$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E34-R23$$9info:eu-repo/grantAgreement/ES/DGA/LMP58_18$$9info:eu-repo/grantAgreement/EC/H2020/101034288/EU/International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus/IberusExperience$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101034288-IberusExperience$$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136362NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127622OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-137973NB-I00
000163793 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000163793 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163793 700__ $$aVeloz, Billy$$uUniversidad de Zaragoza
000163793 700__ $$aSoares, Cátia O.
000163793 700__ $$aGoerdeler, Felix
000163793 700__ $$aGrosso, Ana Sofia
000163793 700__ $$aBüll, Christian
000163793 700__ $$aMiller, Rebecca L.
000163793 700__ $$aFurukawa, Sanae
000163793 700__ $$aGinés-Alcober, Irene
000163793 700__ $$0(orcid)0000-0001-9224-5854$$aTaleb, Víctor
000163793 700__ $$0(orcid)0000-0002-2202-3460$$aMerino, Pedro$$uUniversidad de Zaragoza
000163793 700__ $$0(orcid)0000-0002-2855-4801$$aGhirardello, Mattia$$uUniversidad de Zaragoza
000163793 700__ $$aCompañón, Ismael
000163793 700__ $$aCoelho, Helena
000163793 700__ $$aDias, Jorge S.
000163793 700__ $$aVincentelli, Renaud
000163793 700__ $$aHenrissat, Bernard
000163793 700__ $$aJoshi, Hiren
000163793 700__ $$aClausen, Henrik
000163793 700__ $$aCorzana, Francisco
000163793 700__ $$aMarcelo, Filipa
000163793 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, Ramon
000163793 700__ $$aNarimatsu, Yoshiki
000163793 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000163793 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000163793 773__ $$g16, 1 (2025), [14 pp.]$$tNature communications$$x2041-1723
000163793 8564_ $$s2904451$$uhttps://zaguan.unizar.es/record/163793/files/texto_completo.pdf$$yVersión publicada
000163793 8564_ $$s2518373$$uhttps://zaguan.unizar.es/record/163793/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163793 909CO $$ooai:zaguan.unizar.es:163793$$particulos$$pdriver
000163793 951__ $$a2025-11-07-10:24:47
000163793 980__ $$aARTICLE