163817 20251107115328.0 doi 10.1016/j.measurement.2025.119351 sideral 145967 ART-2025-145967 eng Lillo Otarola, Luis Multi-objective optimization for pressure hold integrity testing of membrane filters in wine bottling 2025 The reliability and reproducibility of integrity tests for hydrophilic membrane filters are essential to ensure the microbiological stability of wine prior to bottling. This study analyzes the testing methodologies used in the Chilean industry, detecting that the pressure hold method is widely adopted but presents high variability and generates false positives under traditional testing conditions. A robust methodological framework based on multi-objective optimization is proposed, explicitly integrating operational uncertainty and instrumental error in determining the optimal testing parameters. The developed model allows the adjustment of test duration and limits according to the specific characteristics of each operation. Results from industrial validations show that the optimized approach eliminates false positives, significantly reduces measurement variability, and provides greater reliability in integrity control. Access copy available to the general public Unrestricted info:eu-repo/semantics/embargoedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Fuente-Mella, Hanns de la Ceroni Díaz, José Marzo Navarro, Mercedes Universidad de Zaragoza (orcid)0000-0002-9628-5738 4011 095 Universidad de Zaragoza Dpto. Direc.Mark.Inves.Mercad. Área Comerci.Investig.Mercados 258, Part E (2025), 119351 [20 pp.] Measurement MEASUREMENT 0263-2241 1258825 http://zaguan.unizar.es/record/163817/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2027-10-30 1514381 http://zaguan.unizar.es/record/163817/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2027-10-30 oai:zaguan.unizar.es:163817 articulos driver 2025-11-07-10:25:17 ARTICLE