000163830 001__ 163830
000163830 005__ 20251107115329.0
000163830 0247_ $$2doi$$a10.1007/s00213-025-06927-3
000163830 0248_ $$2sideral$$a145991
000163830 037__ $$aART-2025-145991
000163830 041__ $$aeng
000163830 100__ $$aMartínez-Caballero, María Ángeles
000163830 245__ $$aVoluntary wheel running prevented the short-term behavioural effects of vicarious intermittent social defeat in female mice
000163830 260__ $$c2025
000163830 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163830 5203_ $$aAbstract
In a previous study, we observed that a Vicarious Intermittent Social Defeat (VISD) protocol induced anxiety- and depression-like symptoms in late adolescent female mice, and in some of them, enhanced sensitivity to cocaine reward in adulthood. Exposure to voluntary physical activity has been shown to mitigate the effects of different stress protocols in both male and female mice. Therefore, the aim of this study was to evaluate the efficacy of a voluntary wheel running (VWR) procedure in preventing the effects of the VISD in female mice. Four groups of female mice were used; (1) mice without exercise (control) nor stress (only exploration of an empty cage) (CONTROL + EXPL); (2) mice without exercise and exposed to VISD on PND 47, 50, 53 and 56 (CONTROL + VISD), (3) mice exposed to VWR (1 h, 3 days/week, from PND 21 to PND 46) without stress (VWR + EXPL); (4) mice exposed to both VWR and VISD (VWR + VISD). On PND 57–58, all female mice performed the Elevated Plus Maze, Hole-Board, Social Interaction, Splash and Object Recognition tests. Three weeks later, all female mice underwent a place conditioning procedure with cocaine. VWR exposure attenuated the VISD-induced reduction in the percentage of time spent in the open arms of the elevated plus maze and prevented the effects of the VISD in the hole-board, splash and object recognition tests. In addition, VWR facilitated the acquisition of the cocaine-induced conditioned place preference. Therefore, access to exercise during adolescence induced protective effects against the short-term negative consequences of social stress in female mice.
000163830 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
000163830 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163830 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163830 700__ $$aCalpe-López, Claudia
000163830 700__ $$aGarcía-Pardo, María Pilar$$uUniversidad de Zaragoza
000163830 700__ $$aArenas, María Carmen
000163830 700__ $$aManzanedo, Carmen
000163830 700__ $$aAguilar, María Asunción
000163830 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000163830 773__ $$g(2025), [11 pp.]$$pPsychopharmacology$$tPsychopharmacology$$x0033-3158
000163830 8564_ $$s1232506$$uhttps://zaguan.unizar.es/record/163830/files/texto_completo.pdf$$yVersión publicada
000163830 8564_ $$s2495026$$uhttps://zaguan.unizar.es/record/163830/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163830 909CO $$ooai:zaguan.unizar.es:163830$$particulos$$pdriver
000163830 951__ $$a2025-11-07-10:25:34
000163830 980__ $$aARTICLE