000163853 001__ 163853
000163853 005__ 20251107115329.0
000163853 0247_ $$2doi$$a10.1016/j.schres.2025.09.019
000163853 0248_ $$2sideral$$a145986
000163853 037__ $$aART-2025-145986
000163853 041__ $$aeng
000163853 100__ $$aSegura, Alex G.
000163853 245__ $$aPolygenic risk score of glycemic homeostasis, Type 2 Diabetes Mellitus and glycemic components in first episode psychosis
000163853 260__ $$c2025
000163853 5203_ $$aObjective
First episode of psychosis (FEP) is associated with glucose homeostasis abnormalities even before pharmacological intervention. Given inconclusive GWAS results regarding a direct genetic link between schizophrenia and type 2 diabetes mellitus (T2DM), we hypothesized that FEP patients may exhibit altered genetic risk for glycemic traits. We compared polygenic risk scores (PRS) for T2DM (PRST2DM), fasting glucose (PRSFG), and glycated hemoglobin (HbA1c) (PRSHbA1c) between FEP patients and controls, examining their associations with glycemic measures over 24 months.
Methods
We analyzed data from 242 FEP patients and 119 controls, assessing fasting serum glucose and HbA1c at baseline and 24 months. We examined cross-sectional and longitudinal associations between PRS and glycemic measures within each group.
Results
FEP patients and controls did not differ significantly in PRS. Significant associations were observed for PRSFG with baseline serum glucose in controls (p = 0.008), PRSFG during follow-up (p = 0.034), PRSHbA1c at 24 months (p = 0.018), and HbA1c longitudinally (p = 0.025). After multiple testing corrections, only the association between PRSFG and baseline serum glucose in controls remained significant (p_adj = 0.023). No associations were found for PRST2DM.
Conclusions
Despite the link between FEP and glycemic disturbances, PRST2DM did not differ between FEP patients and controls. However, PRS for glycemic traits showed associations with glycemic measures in both groups before multiple testing correction, suggesting that genetic predisposition may influence glucose homeostasis in early psychosis. The absence of a direct association between common genetic variants underlying T2DM and early glycemic dysregulation in FEP underscores the importance of considering environmental factors and epigenetic mechanisms.
000163853 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000163853 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163853 700__ $$aVerdolini, Norma
000163853 700__ $$aValli, Isabel
000163853 700__ $$aGarcia-Rizo, Clemente
000163853 700__ $$aDiaz-Caneja, Covadonga M.
000163853 700__ $$aVieta, Eduard
000163853 700__ $$aMezquida, Gisela
000163853 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000163853 700__ $$aGonzalez-Pinto, Ana
000163853 700__ $$aAndreu-Bernabeu, Álvaro
000163853 700__ $$aRoldan, Alejandra
000163853 700__ $$aMartinez-Aran, Anabel
000163853 700__ $$aBaeza, Inmaculada
000163853 700__ $$aMane, Anna
000163853 700__ $$aLabad, Javier
000163853 700__ $$aMüller, Daniel J.
000163853 700__ $$aGuasch-Capella, Nora
000163853 700__ $$aBernardo, Miquel
000163853 700__ $$aMas, Sergi
000163853 700__ $$aBioque, Miquel
000163853 700__ $$aGonzalez, Jairo
000163853 700__ $$aAndrés, Pablo
000163853 700__ $$aCavone, Vito
000163853 700__ $$aCorripio, Iluminada
000163853 700__ $$aDuque, Alejandra
000163853 700__ $$aMar-Barrutia, Lorea
000163853 700__ $$aMarin, Julen
000163853 700__ $$aDe-la-Camara, Concepcion
000163853 700__ $$aVaquero-Puyuelo, David$$uUniversidad de Zaragoza
000163853 700__ $$aRivero, Olga
000163853 700__ $$aFabra, María José Escartí
000163853 700__ $$aTrabsa, Amira
000163853 700__ $$aLegido, Teresa
000163853 700__ $$aForte, M. Florencia
000163853 700__ $$aSerra-Navarro, Maria
000163853 700__ $$ade la Serna, Helena
000163853 700__ $$aCastro-Fornielles, J.
000163853 700__ $$aContreras, Fernando
000163853 700__ $$aGarcía-Portilla, M. Paz
000163853 700__ $$aGonzález-Blanco, Leticia
000163853 700__ $$aEchevarría, Rafael Segarra
000163853 700__ $$aRabadán, Arantzazu Zabala
000163853 700__ $$aRodriguez-Jimenez, Roberto
000163853 700__ $$aMartínez-Gras, Isabel
000163853 700__ $$aUsall, Judith
000163853 700__ $$aBarajas, Anna
000163853 700__ $$aSarro, Salvador
000163853 700__ $$aPomarol-Clotet, Edith
000163853 700__ $$aIbañez, Angela
000163853 700__ $$aCuesta, Manuel J.
000163853 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000163853 773__ $$g285 (2025), 265-275$$pSchizophr. res.$$tSCHIZOPHRENIA RESEARCH$$x0920-9964
000163853 8564_ $$s758296$$uhttps://zaguan.unizar.es/record/163853/files/texto_completo.pdf$$yVersión publicada
000163853 8564_ $$s2357092$$uhttps://zaguan.unizar.es/record/163853/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163853 909CO $$ooai:zaguan.unizar.es:163853$$particulos$$pdriver
000163853 951__ $$a2025-11-07-10:26:01
000163853 980__ $$aARTICLE