000163869 001__ 163869
000163869 005__ 20251107115329.0
000163869 0247_ $$2doi$$a10.1002/jcsm.70079
000163869 0248_ $$2sideral$$a145978
000163869 037__ $$aART-2025-145978
000163869 041__ $$aeng
000163869 100__ $$aMarcos-Perez, Diego
000163869 245__ $$aResistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians
000163869 260__ $$c2025
000163869 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163869 5203_ $$aBackground: Centenarians comprise an age group characterized by exceptional longevity and low age-associated pathologies. However, they still experience physiological decline, and different studies have linked frailty to this population. Exercise interventions reverse frailty and improve functional capacity, but no studies have addressed the effect of an intervention in centenarians. In this study, we assessed the impact of a 12-week resistance exercise intervention in a group of centenarians and characterized their functional capacity as well as the expression of several molecular biomarkers associated with frailty.
Methods: A total of 19 centenarians were enrolled, but 7 of them did not complete the study. The remaining 12 centenarians were randomly assigned to the control or intervention group, which was a 12-week resistance exercise intervention. Molecular biomarkers were measured by qRT-PCR and ELISA.
Results: The intervention group improved their functional capacity measured by Short Physical Performance Battery (SPPB) (post 5.0 vs 2.3 in pre) and Physical Performance and Mobility Examination (PPME) (6.5 vs 3.8), as well as in frailty status studied by Fried Frailty Phenotype (3.0 vs 3.8) and Frailty Trait Scale 5 (FTS5) (post 30.7 vs 34.0 in pre) scales. ANCOVA revealed that the resistance training led to significant improvements in functional capacity scales SPPB (p = 0.01) and PPME (p < 0.001), as well as Fried Frailty Phenotype (p = 0.001) and FTS5 (p = 0.05). Biomarkers related to frailty (EGR1, miR194-5p, miR125b-5p and miR454-3p) and inflammation (IL-6 and IL-1β) showed different expression patterns in centenarians (n = 19) compared to both old (n = 44, average of 79 years old) and young adults (n = 34, average of 29 years old) groups. Notably, the intervention was associated with improvements in frailty and inflammation biomarkers expression. Finally, correlation analyses showed significant associations between all functional and frailty variables, with SPPB correlating with miR454-3p (ρ = 0.73) and FTS5 correlating with miR454-3p (ρ = −0.83), IL-6 (ρ = 0.60) and miR125b-5p (ρ = −0.55).
Conclusions: Our results revealed that resistance exercise intervention enhances functional status and reduces frailty in centenarians, and this is associated with improvements in frailty and inflammation biomarkers.
000163869 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/DTS20-00179$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-PI19-01355$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI22-01905$$9info:eu-repo/grantAgreement/ES/MECD/FPU16-05879$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00$$9info:eu-repo/grantAgreement/ES/MINECO/DEP2016-78309-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-10-00408$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-10-00464$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-10-00496
000163869 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163869 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163869 700__ $$0(orcid)0000-0001-6025-5070$$aHernandez-Vicente, Adrián$$uUniversidad de Zaragoza
000163869 700__ $$aCruces-Salguero, Sara
000163869 700__ $$aLanda, Jon
000163869 700__ $$aBonvini, Michelle
000163869 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodríguez, German$$uUniversidad de Zaragoza
000163869 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000163869 700__ $$aRodriguez-Mañas, Leocadio
000163869 700__ $$aAbizanda, Pedro
000163869 700__ $$aOtaegui, David
000163869 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza
000163869 700__ $$aMatheu, Ander
000163869 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000163869 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000163869 773__ $$g16, 5 (2025), e70079 [6 pp.]$$pJ. cachexia sarcopenia muscle$$tJournal of Cachexia, Sarcopenia and Muscle$$x2190-5991
000163869 8564_ $$s2154033$$uhttps://zaguan.unizar.es/record/163869/files/texto_completo.pdf$$yVersión publicada
000163869 8564_ $$s2723269$$uhttps://zaguan.unizar.es/record/163869/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163869 909CO $$ooai:zaguan.unizar.es:163869$$particulos$$pdriver
000163869 951__ $$a2025-11-07-10:26:20
000163869 980__ $$aARTICLE