163890 20251113160752.0 doi 10.1007/s00216-015-8848-2 sideral 92715 ART-2015-92715 eng Canellas, E. (orcid)0000-0003-2638-9221 UPLC–ESI-Q-TOF-MSE and GC–MS identification and quantification of non-intentionally added substances coming from biodegradable food packaging 2015 Biodegradable packagings are made by combination of several materials creating a multilayer with the properties needed. Each material, including the adhesive, could contain substances that could migrate to the food. In this work, gas chromatography coupled with mass spectrometry and ultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were used to identify the biodegradable adhesive compounds. Five of the 13 compounds identified were nonintentionally added substances; they were neoformed compounds created by the reaction of added compounds in the adhesive. Moreover, the migration of the compounds through four different biodegradable materials—paper, polylactic acid, ecovio®, and polyvinyl alcohol—was studied for the first time. Three of the 13 compounds identified in the adhesive migrated from the adhesive to Tenax®, which was used as a solid food simulant. One of them, 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol, was an intentionally added substance, and the other two were 1, 6-dioxacyclododecane-7, 12-dione and 1, 6, 13, 18-tetraoxacyclotetracosane-7, 12, 19, 24-tetraone, which were nonintentionally added substances identified in this work. Higher migration values (ranging from 0.81 to 2.07 mg/kg) were observed for migration through ecovio® than through the multilayer made by combination of ecovio® and polyvinyl alcohol (0.07–0.39 mg/kg) owing to the barrier effect provided by polyvinyl alcohol. The migration values for migration through paper and polylactic acid were below the limits of detection. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/T10 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.125 2015 CHEMISTRY, ANALYTICAL 15 / 75 = 0.2 2015 Q1 T1 BIOCHEMICAL RESEARCH METHODS 25 / 77 = 0.325 2015 Q2 T1 1.059 2015 Analytical Chemistry 2015 Q1 Biochemistry 2015 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Vera, P. Universidad de Zaragoza (orcid)0000-0002-8765-4319 Nerín, C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 407, 22 (2015), 6781-6790 Anal. Bioanal. Chem. Analytical and Bioanalytical Chemistry 1618-2642 446726 http://zaguan.unizar.es/record/163890/files/texto_completo.pdf Postprint 1816517 http://zaguan.unizar.es/record/163890/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:163890 articulos driver 2025-11-13-14:57:15 ARTICLE