000163896 001__ 163896
000163896 005__ 20251113160752.0
000163896 0247_ $$2doi$$a10.1080/19440049.2017.1308017
000163896 0248_ $$2sideral$$a99750
000163896 037__ $$aART-2017-99750
000163896 041__ $$aeng
000163896 100__ $$0(orcid)0000-0003-2638-9221$$aCanellas, E.
000163896 245__ $$aMigration assessment and the ‘threshold of toxicological concern’ applied to the safe design of an acrylic adhesive for food-contact laminates
000163896 260__ $$c2017
000163896 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163896 5203_ $$aThe suitability of an acrylic adhesive used on food packaging was studied. Six potential migrants were identified using GC-MS and UPLC-QTOF. Five compounds were intentionally added (2-butoxyethanol and 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol 10 (TMDD) and TMDD ethoxylates). One of the compounds identified as 2-(12-(methacryloyloxy) dodecyl)malonic acid was a non -intentionally added substance (NIAS), which could be a methyl metacrylate derivative. A migration study from multilayers containing paper–adhesive–film was carried out. The films used were polyethylene (PE), polypropylene, polyethylene terephthalate, polylactic acid (PLA) and Ecovio F2223®, which is a mixture of biodegradable polyester with PLA. All the non-volatile compounds, including the identified NIAS, migrated into the dry food simulant Tenax ®. Five surfactants based on TMDD were found to migrate from all laminates into Tenax at levels from 0.05 to 0.6 mg kg–1. The results showed that the lowest migration (0.01 mg kg–1 for 2-(12-(methacryloyloxy)dodecyl)malonic acid to 0.07 for TMDD mg kg–1) occurred when the compounds passed through PLA, demonstrating its functional barrier properties to these compounds. In contrast, PE showed the worst barrier properties to these compounds. To evaluate the migration results, the threshold of toxicological concern strategy was applied. The migration values of the surfactant identified were above 0.09 mg kg–1. Thus, it was decided to remove this surfactant from the formulation.
000163896 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000163896 590__ $$a2.129$$b2017
000163896 591__ $$aCHEMISTRY, APPLIED$$b30 / 70 = 0.429$$c2017$$dQ2$$eT2
000163896 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b50 / 133 = 0.376$$c2017$$dQ2$$eT2
000163896 591__ $$aTOXICOLOGY$$b57 / 93 = 0.613$$c2017$$dQ3$$eT2
000163896 592__ $$a0.74$$b2017
000163896 593__ $$aFood Science$$c2017$$dQ1
000163896 593__ $$aToxicology$$c2017$$dQ2
000163896 593__ $$aMedicine (miscellaneous)$$c2017$$dQ2
000163896 593__ $$aPublic Health, Environmental and Occupational Health$$c2017$$dQ2
000163896 593__ $$aChemistry (miscellaneous)$$c2017$$dQ2
000163896 593__ $$aHealth, Toxicology and Mutagenesis$$c2017$$dQ2
000163896 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163896 700__ $$0(orcid)0000-0002-8765-4319$$aVera, P.$$uUniversidad de Zaragoza
000163896 700__ $$0(orcid)0000-0003-2685-5739$$aNerín, C.$$uUniversidad de Zaragoza
000163896 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000163896 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA
000163896 773__ $$g34, 10 (2017), 1721 - 1729$$pFood Addit. Contam., Part A, Analysis control expo. risk assess.$$tFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment$$x1944-0049
000163896 8564_ $$s282448$$uhttps://zaguan.unizar.es/record/163896/files/texto_completo.pdf$$yVersión publicada
000163896 8564_ $$s2876232$$uhttps://zaguan.unizar.es/record/163896/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163896 909CO $$ooai:zaguan.unizar.es:163896$$particulos$$pdriver
000163896 951__ $$a2025-11-13-14:57:22
000163896 980__ $$aARTICLE