163896 20251113160752.0 doi 10.1080/19440049.2017.1308017 sideral 99750 ART-2017-99750 eng Canellas, E. (orcid)0000-0003-2638-9221 Migration assessment and the ‘threshold of toxicological concern’ applied to the safe design of an acrylic adhesive for food-contact laminates 2017 The suitability of an acrylic adhesive used on food packaging was studied. Six potential migrants were identified using GC-MS and UPLC-QTOF. Five compounds were intentionally added (2-butoxyethanol and 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol 10 (TMDD) and TMDD ethoxylates). One of the compounds identified as 2-(12-(methacryloyloxy) dodecyl)malonic acid was a non -intentionally added substance (NIAS), which could be a methyl metacrylate derivative. A migration study from multilayers containing paper–adhesive–film was carried out. The films used were polyethylene (PE), polypropylene, polyethylene terephthalate, polylactic acid (PLA) and Ecovio F2223®, which is a mixture of biodegradable polyester with PLA. All the non-volatile compounds, including the identified NIAS, migrated into the dry food simulant Tenax ®. Five surfactants based on TMDD were found to migrate from all laminates into Tenax at levels from 0.05 to 0.6 mg kg–1. The results showed that the lowest migration (0.01 mg kg–1 for 2-(12-(methacryloyloxy)dodecyl)malonic acid to 0.07 for TMDD mg kg–1) occurred when the compounds passed through PLA, demonstrating its functional barrier properties to these compounds. In contrast, PE showed the worst barrier properties to these compounds. To evaluate the migration results, the threshold of toxicological concern strategy was applied. The migration values of the surfactant identified were above 0.09 mg kg–1. Thus, it was decided to remove this surfactant from the formulation. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.129 2017 CHEMISTRY, APPLIED 30 / 70 = 0.429 2017 Q2 T2 FOOD SCIENCE & TECHNOLOGY 50 / 133 = 0.376 2017 Q2 T2 TOXICOLOGY 57 / 93 = 0.613 2017 Q3 T2 0.74 2017 Food Science 2017 Q1 Toxicology 2017 Q2 Medicine (miscellaneous) 2017 Q2 Public Health, Environmental and Occupational Health 2017 Q2 Chemistry (miscellaneous) 2017 Q2 Health, Toxicology and Mutagenesis 2017 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Vera, P. Universidad de Zaragoza (orcid)0000-0002-8765-4319 Nerín, C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 34, 10 (2017), 1721 - 1729 Food Addit. Contam., Part A, Analysis control expo. risk assess. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 1944-0049 282448 http://zaguan.unizar.es/record/163896/files/texto_completo.pdf Versión publicada 2876232 http://zaguan.unizar.es/record/163896/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:163896 articulos driver 2025-11-13-14:57:22 ARTICLE