doi:10.1007/s00216-013-6881-6engVera, PaulaCanellas, ElenaNerín, CristinaIdentification of non-volatile compounds and their migration from hot melt adhesives used in food packaging materials characterized by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometryART-2013-83982The identification of unknown non-volatile migrant compounds from adhesives used in food contact materials is a very challenging task because of the number of possible compounds involved, given that adhesives are complex mixtures of chemicals. The use of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-MS/QTOF) is shown to be a successful tool for identifying non-targeted migrant compounds from two hot melt adhesives used in food packaging laminates. Out of the seven migrants identified and quantified, five were amides and one was a compound classified in Class II of the Cramer toxicity. None of the migration values exceeded the recommended Cramer exposure values.2013http://zaguan.unizar.es/record/16389810.1007/s00216-013-6881-6http://zaguan.unizar.es/record/163898oai:zaguan.unizar.es:163898Analytical and Bioanalytical Chemistry 405, 14 (2013), 4747-4754by-nc-ndhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esinfo:eu-repo/semantics/openAccess