000163905 001__ 163905 000163905 005__ 20251113160752.0 000163905 0247_ $$2doi$$a10.2174/1570178614666171121144234 000163905 0248_ $$2sideral$$a105854 000163905 037__ $$aART-2018-105854 000163905 041__ $$aeng 000163905 100__ $$0(orcid)0000-0002-2202-3460$$aMerino, P.$$uUniversidad de Zaragoza 000163905 245__ $$aDirect Hydroxymethylation of C=N Double Bonds 000163905 260__ $$c2018 000163905 5203_ $$aDirect hydroxymethylation of C=N double bonds including imines, nitrones, oximes, hydrazones and iminium salts is a less explored synthetic approach to 1, 2-amino alcohols that provides good alternatives to the classical methods. The review deals with nucleophilic additions of organometallic hydroxymethyl reagents and lithiated alkoxyallenes to C=N double bonds. Reductive cross couplings between C=N double bonds and aldehydes or ketones are also discussed. 000163905 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E10$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-R 000163905 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000163905 590__ $$a0.723$$b2018 000163905 591__ $$aCHEMISTRY, ORGANIC$$b52 / 57 = 0.912$$c2018$$dQ4$$eT3 000163905 592__ $$a0.205$$b2018 000163905 593__ $$aOrganic Chemistry$$c2018$$dQ4 000163905 593__ $$aBiochemistry$$c2018$$dQ4 000163905 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000163905 700__ $$0(orcid)0000-0003-3433-6701$$aTejero, T.$$uUniversidad de Zaragoza 000163905 700__ $$0(orcid)0000-0001-8355-2289$$aDelso, I.$$uUniversidad de Zaragoza 000163905 700__ $$0(orcid)0000-0001-7200-7031$$aJuste, V.$$uUniversidad de Zaragoza 000163905 700__ $$0(orcid)0000-0003-4249-6748$$aPedron, M.$$uUniversidad de Zaragoza 000163905 700__ $$0(orcid)0000-0003-2952-7984$$aOrta, S.$$uUniversidad de Zaragoza 000163905 700__ $$0(orcid)0000-0001-7773-9418$$aMatute, R.$$uUniversidad de Zaragoza 000163905 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000163905 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente 000163905 773__ $$g15, 5 (2018), 375-386$$pLETT ORG CHEM$$tLETTERS IN ORGANIC CHEMISTRY$$x1570-1786 000163905 8564_ $$s545798$$uhttps://zaguan.unizar.es/record/163905/files/texto_completo.pdf$$yVersión publicada 000163905 8564_ $$s2217687$$uhttps://zaguan.unizar.es/record/163905/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000163905 909CO $$ooai:zaguan.unizar.es:163905$$particulos$$pdriver 000163905 951__ $$a2025-11-13-14:57:33 000163905 980__ $$aARTICLE