doi:10.2174/1570178614666171121144234engMerino, P.Tejero, T.Delso, I.Juste, V.Pedron, M.Orta, S.Matute, R.Direct Hydroxymethylation of C=N Double BondsART-2018-105854Direct hydroxymethylation of C=N double bonds including imines, nitrones, oximes, hydrazones and iminium salts is a less explored synthetic approach to 1, 2-amino alcohols that provides good alternatives to the classical methods. The review deals with nucleophilic additions of organometallic hydroxymethyl reagents and lithiated alkoxyallenes to C=N double bonds. Reductive cross couplings between C=N double bonds and aldehydes or ketones are also discussed.2018http://zaguan.unizar.es/record/16390510.2174/1570178614666171121144234http://zaguan.unizar.es/record/163905oai:zaguan.unizar.es:163905info:eu-repo/grantAgreement/ES/DGA/E10info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-RLETTERS IN ORGANIC CHEMISTRY 15, 5 (2018), 375-386All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/closedAccess