163913 20251113160752.0 doi 10.1016/j.talanta.2019.06.103 sideral 114111 ART-2019-114111 eng Canellas, E. Universidad de Zaragoza (orcid)0000-0003-2638-9221 Ion mobility quadrupole time-of-flight mass spectrometry for the identification of non-intentionally added substances in UV varnishes applied on food contact materials. A safety by design study 2019 Varnishes are normally applied on printed food packaging to protect it from smearing and scratching. Moreover, they may be applied on the food contact surface in order to improve resistance towards moisture and fat. Some of the compounds that make up the varnish formulation could migrate to the food. In this work, the ion mobility quadrupole time-of-flight mass spectrometry has been used to obtain drift time-aligned mass spectra in which accurate the mass of precursor ions and their fragments are used to identify both intentionally and non-intentionally added substances (NIAS). The compound 2-propenoic acid, 1, 1''-[2-[[3-[2, 2-bis[[(1-oxo-2-propen-1-yl)oxy]methyl]butoxy]-1-oxopropoxy]methyl-2-ethyl-1, 3-propanediyl] ester was identified as a NIAS formed from the varnish monomer 2-propenoic acid, 1, 1''[2-ethyl-2-[[(1-oxo-2-propen-1-yl)oxy]methyl]-1, 3-propanediyl] ester. The compound 5, 11-diethyl-7-oxo-4, 6, 10, 12-tetraoxopentadecane-3, 13-diyl diacrylate is a NIAS derived from the varnish monomer 2-propenoic acid, 1, 1''-[oxybis(methyl-2, 1-ethanediyl)] ester, and was found to migrate into the food simulant tested at a level of 0.03 mg kg(-1). Finally, the NIAS, 2-{2- [2-(acryloyloxy)-1-methylethoxy]-1-methylethoxy)-1-methylethyl acrylate, an impaity of a photoinitiator used for UV curing of the varnish, was identified, and its migration of 0.14 mg kg(-1) exceeded the threshold established as safe for human consumption. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/T53-17R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 5.339 2019 CHEMISTRY, ANALYTICAL 11 / 86 = 0.128 2019 Q1 T1 1.178 2019 Analytical Chemistry 2019 Q1 Spectroscopy 2019 Q1 Biochemistry 2019 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Vera, P. Universidad de Zaragoza (orcid)0000-0002-8765-4319 Nerin, C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 205 (2019), 120103 [9 pp.] Talanta Talanta 0039-9140 652898 http://zaguan.unizar.es/record/163913/files/texto_completo.pdf Postprint 2563969 http://zaguan.unizar.es/record/163913/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:163913 articulos driver 2025-11-13-14:57:43 ARTICLE