000163917 001__ 163917 000163917 005__ 20251113160752.0 000163917 0247_ $$2doi$$a10.1021/acs.analchem.0c00532 000163917 0248_ $$2sideral$$a117613 000163917 037__ $$aART-2020-117613 000163917 041__ $$aeng 000163917 100__ $$aSu, Q.Z. 000163917 245__ $$aDirect Immersion-Solid-Phase Microextraction Coupled to Gas Chromatography-Mass Spectrometry and Response Surface Methodology for Nontarget Screening of (Semi-) Volatile Migrants from Food Contact Materials 000163917 260__ $$c2020 000163917 5060_ $$aAccess copy available to the general public$$fUnrestricted 000163917 5203_ $$aToward a more rigorous inspection of food contact materials, the importance of sample preparation for nontarget screening should be addressed. Direct immersion-solid-phase microextraction coupled to gas chromatography mass spectrometry (DI-SPME-GC-MS) was optimized for nontarget screening of migrants in 3% acetic acid, 10% ethanol, and 95% ethanol food simulants by response surface methodology (RSM) in the present study. Optimum conditions were DVB/CAR/PDMS fiber, no pH adjustment for 10% and 95% ethanol simulant but pH adjustment to 7 for 3% acetic acid simulant, no salt addition, 5 min preincubation, 55 min extraction at 70 degrees C, and 8 min desorption at 250 degrees C. In addition, 9.5 times dilution of 95% ethanol samples prior to extraction was required. pH modification of 3% acetic acid samples was found to be critical for the extraction of amines. The proposed methodology was then evaluated by determining the limit of detection (LOD) as well as repeatability of 35 food contact materials-related substances. Except for those amines and diols which have a relatively high LOD, the LODs of the rest of the substances were 0.1-14.1 mu g/kg with a precision of 1.9-23.0% in 10% ethanol and were 0.1-20.2 mu g/kg with a precision of 2.5-19.6% in 3% acetic acid simulant. The LOD and precision in 95% ethanol simulant were 0.7-163.7 mu g/kg and 1.4-26.8%, respectively. The proposed method can be applied for an overall screening of migrants from these three simulants at even trace levels, though attention should be paid to some specific analytes, e.g., diols and amines, which could have a high LOD and toxicity. 000163917 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000163917 590__ $$a6.986$$b2020 000163917 591__ $$aCHEMISTRY, ANALYTICAL$$b8 / 83 = 0.096$$c2020$$dQ1$$eT1 000163917 592__ $$a2.117$$b2020 000163917 593__ $$aAnalytical Chemistry$$c2020$$dQ1 000163917 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000163917 700__ $$0(orcid)0000-0002-8765-4319$$aVera, P.$$uUniversidad de Zaragoza 000163917 700__ $$0(orcid)0000-0003-2685-5739$$aNerin, C.$$uUniversidad de Zaragoza 000163917 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000163917 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA 000163917 773__ $$g92, 7 (2020), 5577-5584$$pAnal. chem.$$tANALYTICAL CHEMISTRY$$x0003-2700 000163917 8564_ $$s438498$$uhttps://zaguan.unizar.es/record/163917/files/texto_completo.pdf$$yPostprint 000163917 8564_ $$s1926380$$uhttps://zaguan.unizar.es/record/163917/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000163917 909CO $$ooai:zaguan.unizar.es:163917$$particulos$$pdriver 000163917 951__ $$a2025-11-13-14:57:48 000163917 980__ $$aARTICLE