000163920 001__ 163920 000163920 005__ 20251113160752.0 000163920 0247_ $$2doi$$a10.1016/j.chroma.2019.460778 000163920 0248_ $$2sideral$$a117811 000163920 037__ $$aART-2020-117811 000163920 041__ $$aeng 000163920 100__ $$0(orcid)0000-0003-2638-9221$$aCanellas, Elena$$uUniversidad de Zaragoza 000163920 245__ $$aIon mobility quadrupole time-of-flight high resolution mass spectrometry coupled to ultra-high pressure liquid chromatography for identification of non-intentionally added substances migrating from food cans 000163920 260__ $$c2020 000163920 5060_ $$aAccess copy available to the general public$$fUnrestricted 000163920 5203_ $$aSealants, incorporated in the lids of food cans to ensure the can is hermetically sealed, are formulated from a wide variety of compounds. These compounds and associated non-intentionally added substances (NIAS) could migrate to the food contained in the can. In this work, ion mobility quadrupole time-of-flight mass spectrometry coupled to ultra-high performance liquid chromatography (UHPLC-IM-QTOF-MS) has been used to obtain ion mobility filtered extracted ion chromatograms. Subsequently, accurate mass precursor ions and their fragments have been used to identify the compounds migrating from the sealant to the content of the cans. Moreover, the correlation between the collision cross-section (CCS) values and m/z of the compounds was used to increase the level of confidence of the identification. Seven compounds were found to have migrated to the food simulants. The compounds bis(2-hydroxy-3-tert-butyl-5-methylphenyl)dicyclopentane, 1-tetradecanesulfonic acid, 1-pentadecanesulfonic acid, 1-hexadecanesulfonic acid and naphthalene-2-sulfonic acid (whose migration was over the specific migration limit established by the European Regulation 10/2011/EU) were identified as NIAS in the food simulants studied. 000163920 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T53-17R 000163920 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000163920 590__ $$a4.759$$b2020 000163920 591__ $$aCHEMISTRY, ANALYTICAL$$b17 / 83 = 0.205$$c2020$$dQ1$$eT1 000163920 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b13 / 77 = 0.169$$c2020$$dQ1$$eT1 000163920 592__ $$a1.01$$b2020 000163920 593__ $$aAnalytical Chemistry$$c2020$$dQ1 000163920 593__ $$aOrganic Chemistry$$c2020$$dQ1 000163920 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000163920 593__ $$aBiochemistry$$c2020$$dQ1 000163920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000163920 700__ $$0(orcid)0000-0002-8765-4319$$aVera, Paula$$uUniversidad de Zaragoza 000163920 700__ $$0(orcid)0000-0003-2685-5739$$aNerín, Cristina$$uUniversidad de Zaragoza 000163920 700__ $$aDreolin, Nicola 000163920 700__ $$aGoshawk, Jeff 000163920 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000163920 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA 000163920 773__ $$g1616 (2020), Art. 460778 [7 pp.]$$pJ. chromatogr. A$$tJournal of Chromatography A$$x0021-9673 000163920 8564_ $$s333771$$uhttps://zaguan.unizar.es/record/163920/files/texto_completo.pdf$$yPostprint 000163920 8564_ $$s2450492$$uhttps://zaguan.unizar.es/record/163920/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000163920 909CO $$ooai:zaguan.unizar.es:163920$$particulos$$pdriver 000163920 951__ $$a2025-11-13-14:57:51 000163920 980__ $$aARTICLE