163920 20251113160752.0 doi 10.1016/j.chroma.2019.460778 sideral 117811 ART-2020-117811 eng Canellas, Elena Universidad de Zaragoza (orcid)0000-0003-2638-9221 Ion mobility quadrupole time-of-flight high resolution mass spectrometry coupled to ultra-high pressure liquid chromatography for identification of non-intentionally added substances migrating from food cans 2020 Sealants, incorporated in the lids of food cans to ensure the can is hermetically sealed, are formulated from a wide variety of compounds. These compounds and associated non-intentionally added substances (NIAS) could migrate to the food contained in the can. In this work, ion mobility quadrupole time-of-flight mass spectrometry coupled to ultra-high performance liquid chromatography (UHPLC-IM-QTOF-MS) has been used to obtain ion mobility filtered extracted ion chromatograms. Subsequently, accurate mass precursor ions and their fragments have been used to identify the compounds migrating from the sealant to the content of the cans. Moreover, the correlation between the collision cross-section (CCS) values and m/z of the compounds was used to increase the level of confidence of the identification. Seven compounds were found to have migrated to the food simulants. The compounds bis(2-hydroxy-3-tert-butyl-5-methylphenyl)dicyclopentane, 1-tetradecanesulfonic acid, 1-pentadecanesulfonic acid, 1-hexadecanesulfonic acid and naphthalene-2-sulfonic acid (whose migration was over the specific migration limit established by the European Regulation 10/2011/EU) were identified as NIAS in the food simulants studied. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA-FEDER/T53-17R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 4.759 2020 CHEMISTRY, ANALYTICAL 17 / 83 = 0.205 2020 Q1 T1 BIOCHEMICAL RESEARCH METHODS 13 / 77 = 0.169 2020 Q1 T1 1.01 2020 Analytical Chemistry 2020 Q1 Organic Chemistry 2020 Q1 Medicine (miscellaneous) 2020 Q1 Biochemistry 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Vera, Paula Universidad de Zaragoza (orcid)0000-0002-8765-4319 Nerín, Cristina Universidad de Zaragoza (orcid)0000-0003-2685-5739 Dreolin, Nicola Goshawk, Jeff 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 1616 (2020), Art. 460778 [7 pp.] J. chromatogr. A Journal of Chromatography A 0021-9673 333771 http://zaguan.unizar.es/record/163920/files/texto_completo.pdf Postprint 2450492 http://zaguan.unizar.es/record/163920/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:163920 articulos driver 2025-11-13-14:57:51 ARTICLE