000163953 001__ 163953
000163953 005__ 20251113160752.0
000163953 0247_ $$2doi$$a10.31083/FBL47074
000163953 0248_ $$2sideral$$a146102
000163953 037__ $$aART-2025-146102
000163953 041__ $$aeng
000163953 100__ $$aMonzón, Marta
000163953 245__ $$aChanges of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease
000163953 260__ $$c2025
000163953 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163953 5203_ $$aBackground: In recent years, neuroglia has become a therapeutic target for neurodegenerative diseases. Despite the recognition of a variety of microglial morphologies associated with the neuroinflammatory process that involve diverse functionalities for this glial type, it is still unknown its beneficial or harmful role to the surrounding tissue. Methods: The study presented here proposes a novel approach to the neurodegenerative progression based on the reliability of its results due to the use of a natural model. Morphological alterations in microglia were assessed in cerebellar samples from prion-affected individuals at different stages of the natural disease (pre-clinical, clinical and terminal). Results: Immunohistochemical profiles confirmed that the abundance and morphology of the cells were found irrespective of the stage of the disease. Only an evident association of dystrophic pattern with advanced stages of the neurodegenerative process of scrapie was consistently demonstrated. Conclusions: Overall, we conclude that the observations described here support a potential failure of microglial cells that could perhaps lead to their inability to perform some of their physiological functions, maybe due to a senescent state. Gaining insight into the multifaceted roles of neuroglia in central nervous system (CNS) diseases is of critical importance in knowledge and understanding of CNS disease pathogenesis, but also in generating novel therapeutic strategies.
000163953 536__ $$9info:eu-repo/grantAgreement/ES/UZ/2014-BIO-4
000163953 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163953 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163953 700__ $$aPérez, Juan Sauca
000163953 700__ $$aHernández, Rodrigo S.
000163953 700__ $$aSarasa, Rocío
000163953 700__ $$aGarcés, Moisés
000163953 700__ $$aLuesma, M José
000163953 700__ $$aBadiola, Juan J
000163953 773__ $$g30, 10 (2025), 47074 [9 pp.]$$pFront. Biosci.$$tFrontiers in Bioscience-Landmark$$x2768-6701
000163953 8564_ $$s13283693$$uhttps://zaguan.unizar.es/record/163953/files/texto_completo.pdf$$yVersión publicada
000163953 8564_ $$s3137531$$uhttps://zaguan.unizar.es/record/163953/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163953 909CO $$ooai:zaguan.unizar.es:163953$$particulos$$pdriver
000163953 951__ $$a2025-11-13-14:58:29
000163953 980__ $$aARTICLE