000163968 001__ 163968
000163968 005__ 20251113160753.0
000163968 0247_ $$2doi$$a10.3390/nu15214665
000163968 0248_ $$2sideral$$a146064
000163968 037__ $$aART-2023-146064
000163968 041__ $$aeng
000163968 100__ $$aLopez-Delgado, Juan Carlos
000163968 245__ $$aParenteral Nutrition: Current Use, Complications, and Nutrition Delivery in Critically Ill Patients
000163968 260__ $$c2023
000163968 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163968 5203_ $$aBackground: Parenteral nutrition (PN) is needed to avoid the development of malnutrition when enteral nutrition (EN) is not possible. Our main aim was to assess the current use, complications, and nutrition delivery associated with PN administration in adult critically ill patients, especially when used early and as the initial route. We also assessed the differences between patients who received only PN and those in whom EN was initiated after PN (PN-EN). Methods: A multicenter (n = 37) prospective observational study was performed. Patient clinical characteristics, outcomes, and nutrition-related variables were recorded. Statistical differences between subgroups were analyzed accordingly. Results: From the entire population (n = 629), 186 (29.6%) patients received PN as initial nutrition therapy. Of these, 74 patients (11.7%) also received EN during their ICU stay (i.e., PN-EN subgroup). PN was administered early (<48 h) in the majority of patients (75.3%; n = 140) and the mean caloric (19.94 ± 6.72 Kcal/kg/day) and protein (1.01 ± 0.41 g/kg/day) delivery was similar to other contemporary studies. PN showed similar nutritional delivery when compared with the enteral route. No significant complications were associated with the use of PN. Thirty-two patients (43.3%) presented with EN-related complications in the PN-EN subgroup but received a higher mean protein delivery (0.95 ± 0.43 vs 1.17 ± 0.36 g/kg/day; p = 0.03) compared with PN alone. Once adjusted for confounding factors, patients who received PN alone had a lower mean protein intake (hazard ratio (HR): 0.29; 95% confidence interval (CI): 0.18–0.47; p = 0.001), shorter ICU stay (HR: 0.96; 95% CI: 0.91–0.99; p = 0.008), and fewer days on mechanical ventilation (HR: 0.85; 95% CI: 0.81–0.89; p = 0.001) compared with the PN-EN subgroup. Conclusion: The parenteral route may be safe, even when administered early, and may provide adequate nutrition delivery. Additional EN, when possible, may optimize protein requirements, especially in more severe patients who received initial PN and are expected to have longer ICU stays. NCT Registry: 03634943.
000163968 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000163968 590__ $$a4.8$$b2023
000163968 591__ $$aNUTRITION & DIETETICS$$b18 / 114 = 0.158$$c2023$$dQ1$$eT1
000163968 592__ $$a1.301$$b2023
000163968 593__ $$aNutrition and Dietetics$$c2023$$dQ1
000163968 593__ $$aFood Science$$c2023$$dQ1
000163968 594__ $$a9.2$$b2023
000163968 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000163968 700__ $$aGrau-Carmona, Teodoro
000163968 700__ $$aMor-Marco, Esther
000163968 700__ $$aBordeje-Laguna, Maria Luisa
000163968 700__ $$aPortugal-Rodriguez, Esther
000163968 700__ $$aLorencio-Cardenas, Carol
000163968 700__ $$aVera-Artazcoz, Paula
000163968 700__ $$aMacaya-Redin, Laura
000163968 700__ $$aLlorente-Ruiz, Beatriz
000163968 700__ $$aIglesias-Rodriguez, Rayden
000163968 700__ $$aMonge-Donaire, Diana
000163968 700__ $$aMartinez-Carmona, Juan Francisco
000163968 700__ $$aSanchez-Ales, Laura
000163968 700__ $$aSanchez-Miralles, Angel
000163968 700__ $$aCrespo-Gomez, Monica
000163968 700__ $$aLeon-Cinto, Cristina
000163968 700__ $$aFlordelis-Lasierra, Jose Luis
000163968 700__ $$aServia-Goixart, Lluis
000163968 700__ $$0(orcid)0000-0002-8068-5016$$aSerón Arbeloa, Carlos$$uUniversidad de Zaragoza
000163968 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000163968 773__ $$g15, 21 (2023), 4665 [15 pp.]$$pNutrients$$tNutrients$$x2072-6643
000163968 8564_ $$s927890$$uhttps://zaguan.unizar.es/record/163968/files/texto_completo.pdf$$yVersión publicada
000163968 8564_ $$s2849071$$uhttps://zaguan.unizar.es/record/163968/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000163968 909CO $$ooai:zaguan.unizar.es:163968$$particulos$$pdriver
000163968 951__ $$a2025-11-13-14:58:46
000163968 980__ $$aARTICLE