doi:10.1002/smll.202509070engBescós-Ramo, SaraTurriani, MarcoParmeggiani, CamillaPiñol, MilagrosOriol, LuisMartella, DanieleAn Amino‐Yne Click Chemistry Approach for Multi‐Responsive Liquid Crystal Elastomer ActuatorsART-2025-146103The spontaneous amino-yne click reaction is introduced for the first time as a fast, efficient, and ambient temperature strategy for preparing multi-responsive Liquid Crystal Elastomer (LCE) actuators. This synthetic approach relies on the amino-yne cross-linking between secondary amines along the main chain of poly(β-amino ester) liquid crystal oligomers and a dipropiolate-functionalized cross-linker, rendering β-aminoacrylate cross-linking points. After alignment and locking via dynamic transesterification at 30 °C, the resulting LCE actuators exhibit reversible and reproducible thermal and light-induced actuation. The generated tension and activation kinetics are easily tunable by adjusting the cross-linker content. Additionally, leveraging the acid-triggered reactivity of the network enables it to respond to additional stimuli, including water-driven actuation. By integrating the capability for dynamic bond exchange, this LCE formulation opens new avenues for designing structures with complex molecular orientation patterns. As a proof of concept, a star-shaped soft actuator is fabricated, demonstrating diverse programmable actuation modes.2025http://zaguan.unizar.es/record/16397010.1002/smll.202509070http://zaguan.unizar.es/record/163970oai:zaguan.unizar.es:163970info:eu-repo/grantAgreement/ES/DGA/E47-23Rinfo:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-SSmall (2025), e09070 [11 pp.]byhttps://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccess