000164018 001__ 164018
000164018 005__ 20251121161350.0
000164018 0247_ $$2doi$$a10.1186/s12889-025-24351-2
000164018 0248_ $$2sideral$$a146134
000164018 037__ $$aART-2025-146134
000164018 041__ $$aeng
000164018 100__ $$0(orcid)0000-0001-6173-5850$$aDe Miguel-Etayo, Pilar
000164018 245__ $$aMELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial
000164018 260__ $$c2025
000164018 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164018 5203_ $$aBackground
Childhood obesity is a significant public health challenge, with Mediterranean countries showing high prevalence rates. While genetic factors play a role, diet and physical activity (PA) are critical modifiable influences. Emphasizing healthy dietary patterns, like the Mediterranean diet, and promoting regular PA can help mitigate obesity risk.
Methods
MELI-POP is a randomized controlled multi-center clinical trial in a cohort of children aged 3 to 6 years at baseline and being at obesity risk. The main objective consists on assessing the efficacy of an intervention during early childhood, considering a healthy lifestyle based on the promotion of a Mediterranean dietary pattern and regular PA, compared with a control group, on decreasing obesity incidence 5 and 10 years after the beginning of the intervention. It is expected to include 310 children, aged 3 to 6 years, having at baseline a normal weight or overweight according to the International Obesity Task Force (IOTF) criteria, and at least one parent having a body mass index > 25 kg/m2. The clinical trial has two arms and is performed in Spanish Primary Health Care centers. The control group receive usual care by healthcare professionals. The intervention group receive education on Mediterranean diet and PA, combined with the provision of extra-virgin olive oil and fish, in order to be consumed at least 2 times per week. Free PA sessions with a physical education teacher are also offered for the children (3 sessions of 60 min of moderate-vigorous PA per week). The participants’ adherence to the intervention is periodically monitored. The study primarily focuses on adiposity as the main outcome, with secondary outcomes encompassing dietary intake and eating habits, physical activity and lifestyle behaviors (including extracurricular sports, screen time, and sleep duration), physical fitness, biochemical parameters (such as inflammation and cardiometabolic biomarkers, fatty acids, and oxidation), as well as microbiota, genetic, omic and metabolomic analyses.
Discussion
Beneficial results are expected by preventing obesity during childhood, and associated comorbidities.
000164018 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-00666$$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-00930$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-00912$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01337
000164018 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000164018 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164018 700__ $$aFlores-Rojas, Katherine
000164018 700__ $$aVázquez-Cobela, Rocío
000164018 700__ $$aJurado-Castro, Jose Manuel
000164018 700__ $$aLarruy-García, Alicia
000164018 700__ $$aPicans-Leis, Rosaura
000164018 700__ $$aCastro-Collado, Cristina
000164018 700__ $$aPastor-Villaescusa, Belén
000164018 700__ $$aLlorente-Cantarero, Francisco Jesus
000164018 700__ $$aAguilera, Concepción M.
000164018 700__ $$aGil-Campos, Mercedes
000164018 700__ $$aLeis, Rosaura
000164018 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000164018 700__ $$aVucinic, V.
000164018 700__ $$aMiguel Berges, M. L.
000164018 700__ $$aManeschy, I.
000164018 700__ $$aJimeno-Martinez, A.
000164018 700__ $$aCórdoba, D.
000164018 700__ $$aAyala-Marín, A.
000164018 700__ $$aSeral-Cortés, M.
000164018 700__ $$aBenedicto, I.
000164018 700__ $$aBueno Lozano, G.
000164018 700__ $$aBlasco Pérez-Aramendia, M. J.
000164018 700__ $$aBartolomé Lalanza, M. L.
000164018 700__ $$aLobera, P.
000164018 700__ $$aLópez-Campos, M.
000164018 700__ $$aMartinez, N.
000164018 700__ $$aLostal, I.
000164018 700__ $$aRamírez, A. I.
000164018 700__ $$aGastón Faci, A. I.
000164018 700__ $$aAtance Melendo, E.
000164018 700__ $$aZapata Mallen, E.
000164018 700__ $$aPardos Romano, R.
000164018 700__ $$aAlutiz Lapeña, L. M.
000164018 700__ $$aViñas, C.
000164018 700__ $$aOlmo Pérez, E.
000164018 700__ $$aSantaliestra-Pasías, A.
000164018 700__ $$aMatute Llorente, Á
000164018 700__ $$aAgüero González de Lafuente, A.
000164018 700__ $$aRico Díaz, J.
000164018 700__ $$aGarcía García, E. M.
000164018 700__ $$aFernández Seijas, O.
000164018 700__ $$aIzquierdo López, I.
000164018 700__ $$aRomero Agrelo, A.
000164018 700__ $$aRivas Rodríguez, L.
000164018 700__ $$aMosteiro Losada, S.
000164018 700__ $$aDe la Torre-Aguilar, MJ.
000164018 700__ $$aAlarcón-Roldán, MA.
000164018 700__ $$aCortés Sillero, M. J.
000164018 700__ $$aCarmona Priego, A.
000164018 700__ $$aBabio, N.
000164018 700__ $$aDe las Heras-Delgado, S.
000164018 700__ $$aGil-Segura, M.
000164018 700__ $$aMena-Sánchez, G.
000164018 700__ $$aPedraza, A.
000164018 700__ $$aSalas-Salvadó, J.
000164018 700__ $$aSalvadó, O.
000164018 700__ $$aValverde-Aguilera, I.
000164018 700__ $$aBustos-Aibar, M.
000164018 700__ $$aTorres-Martos, Á.
000164018 700__ $$aRico, M. C.
000164018 700__ $$aSánchez-Rodríguez, E.
000164018 700__ $$aRueda-De Torre, I.
000164018 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000164018 773__ $$g25, 3791 (2025), [13 pp.]$$pBMC Public Health$$tBMC PUBLIC HEALTH$$x1471-2458
000164018 8564_ $$s1370300$$uhttps://zaguan.unizar.es/record/164018/files/texto_completo.pdf$$yVersión publicada
000164018 8564_ $$s2125843$$uhttps://zaguan.unizar.es/record/164018/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164018 909CO $$ooai:zaguan.unizar.es:164018$$particulos$$pdriver
000164018 951__ $$a2025-11-21-14:24:52
000164018 980__ $$aARTICLE