164023 20251121161350.0 doi 10.1002/smll.202511176 sideral 146274 ART-2025-146274 eng Rossi, Ruggero Light‐mediated supramolecular functionalization of polymerization‐induced self‐assembled micelles 2025 Precise, remote control of polymeric nanoparticles via external stimuli is a key aim for the next-generation drug delivery. As a versatile, one-pot method, polymerization-induced self-assembly (PISA) produces dispersions of block-copolymer micelles at high solids content with tunable core–corona architectures. Light is an ideal trigger to control the uptake and delivery of specific molecules inside such micelles since it can be localized, and easily tuned in intensity and wavelength. In this study, PISA is employed in water to obtain micelles containing diacylaminopyridine units functionalizable thanks to supramolecular interaction by a light-mediated process. Indeed, only if UV irradiation is used to convert thymine-based azo photoswitches into the cis form, these molecules permeate the hydrophilic corona and anchor via hydrogen bonds to the hydrophobic core of the micelles. Subsequent visible‑light exposure regenerates their trans state without micelle disassembling. The photoswitch loading boosts the encapsulation of Nile Red, studied here as a model of hydrophobic cargo, while a subsequent UV light stimulus accelerates the dye release; moreover, the selected photoswitch sustains release over days without further irradiation. By marrying advanced polymerization techniques with reversible photochemistry, dynamic micelles are prepared whose structure and cargo release can be fully controlled by light. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E47-23R info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1 info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00 info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Abad, Miriam Universidad de Zaragoza (orcid)0000-0002-8677-3316 Oriol, Luis Universidad de Zaragoza (orcid)0000-0002-0922-5615 Martella, Daniele Parmeggiani, Camilla Piñol, Milagros Universidad de Zaragoza (orcid)0000-0001-5556-2172 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica e11176 (2025), [10 pp.] Small Small 1613-6810 2731362 http://zaguan.unizar.es/record/164023/files/texto_completo.pdf Versión publicada 2697134 http://zaguan.unizar.es/record/164023/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:164023 articulos driver 2025-11-21-14:24:58 ARTICLE