000164043 001__ 164043
000164043 005__ 20251121161351.0
000164043 0247_ $$2doi$$a10.1021/acs.orglett.5c03814
000164043 0248_ $$2sideral$$a146306
000164043 037__ $$aART-2025-146306
000164043 041__ $$aeng
000164043 100__ $$aAscaso-Alegre, Christian
000164043 245__ $$aScope and Synthetic Applications of the Aryl-Alcohol Oxidase from <i>Streptomyces hiroshimensis</i> ( <i>Sh</i> AAO)
000164043 260__ $$c2025
000164043 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164043 5203_ $$aThe sustainable production of carbonyl compounds is of growing interest due to their broad academic and industrial interest. Herein, we explored the aryl-alcohol oxidase from Streptomyces hiroshimensis (ShAAO), mapping its activity across diverse alcohols, revealing a distinct profile from other natural AAOs. Integrated into tandem organocatalytic processes, ShAAO enabled the synthesis of various chiral compounds, including an intermediate for paroxetine. Gram-scale reactions delivered high yields and turnover numbers exceeding 65000. Immobilization further enhanced stability, highlighting ShAAO as an efficient and industrially relevant biocatalyst.
000164043 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147471NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-136369NB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130803B-I00
000164043 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000164043 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164043 700__ $$aCinca-Fernando, Paula$$uUniversidad de Zaragoza
000164043 700__ $$aRoberts, Tom L.
000164043 700__ $$aLópez-Fernández, Pablo
000164043 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel
000164043 700__ $$aCosgrove, Sebastian C.
000164043 700__ $$0(orcid)0000-0003-4076-6118$$aFerreira, Patricia$$uUniversidad de Zaragoza
000164043 700__ $$0(orcid)0000-0002-3364-1512$$aMangas-Sánchez, Juan
000164043 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000164043 773__ $$g27, 43 (2025), 12086-12091$$pOrg. lett.$$tORGANIC LETTERS$$x1523-7060
000164043 8564_ $$s2394257$$uhttps://zaguan.unizar.es/record/164043/files/texto_completo.pdf$$yVersión publicada
000164043 8564_ $$s3288600$$uhttps://zaguan.unizar.es/record/164043/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164043 909CO $$ooai:zaguan.unizar.es:164043$$particulos$$pdriver
000164043 951__ $$a2025-11-21-14:25:22
000164043 980__ $$aARTICLE