000164081 001__ 164081
000164081 005__ 20251121161351.0
000164081 0247_ $$2doi$$a10.1002/cctc.202501060
000164081 0248_ $$2sideral$$a146225
000164081 037__ $$aART-2025-146225
000164081 041__ $$aeng
000164081 100__ $$0(orcid)0000-0002-0904-9180$$aArdevines, Sandra$$uUniversidad de Zaragoza
000164081 245__ $$aExploring the role of halogen bond donors in the thiourea‐catalyzed Friedel–Crafts alkylation reaction
000164081 260__ $$c2025
000164081 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164081 5203_ $$aHalogen bonding (XB) has recently emerged as a powerful tool in organocatalysis, though asymmetric applications remain scarce. Here we report the first synergistic system combining a chiral thiourea and an inert XB donor. The iodine derivative enhances substrate activation via LP(I)→π*(C = C) interactions. Instead, a strong π–π interaction between the catalysts rules out direct thiourea activation. Applied to asymmetric Friedel–Crafts alkylation, iodoethynyl cocatalysts boost both reactivity and enantioselectivity. DFT calculations rationalize the crucial role of the XB donor, highlighting a new strategy to exploit non‐covalent interactions in asymmetric synthesis.
000164081 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2022-139318NB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147471NB-I00
000164081 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000164081 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000164081 700__ $$aGonzález-Pinardo, Daniel
000164081 700__ $$aFernández, Israel
000164081 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000164081 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel
000164081 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000164081 773__ $$ge01060 (2025), [8 p.]$$pChemCatChem$$tChemCatChem$$x1867-3880
000164081 8564_ $$s795117$$uhttps://zaguan.unizar.es/record/164081/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-10-30
000164081 8564_ $$s2421851$$uhttps://zaguan.unizar.es/record/164081/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-10-30
000164081 909CO $$ooai:zaguan.unizar.es:164081$$particulos$$pdriver
000164081 951__ $$a2025-11-21-14:26:06
000164081 980__ $$aARTICLE