000164111 001__ 164111
000164111 005__ 20251121161351.0
000164111 0247_ $$2doi$$a10.3390/antiox14091097
000164111 0248_ $$2sideral$$a146266
000164111 037__ $$aART-2025-146266
000164111 041__ $$aeng
000164111 100__ $$aEscalera-Moreno, Nieves
000164111 245__ $$aMaternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring
000164111 260__ $$c2025
000164111 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164111 5203_ $$aThe impact of maternal dietary restriction and hydroxytyrosol (HT) supplementation during the last third of gestation on plasma malondialdehyde (MDA) concentration, total antioxidant capacity (ABTS assay), and peripheral blood gene expression related to antioxidant defence, immune response, and energy metabolism was evaluated in beef cows and calves. Two feeding treatments in late gestation (T100% vs. T60% of nutrient requirements) and two HT levels (Control vs. HT at 180 mg/kg of diet) were evaluated during gestation (n = 46 cows) and lactation (n = 37 cows and calves). In pregnant cows, undernutrition led to inhibition of glucose oxidation (PDK4), decreased lipid synthesis (HMGCS1 and SCD) and TLR signalling; T60% cows showed higher plasma MDA (p < 0.05) with no positive effect of HT on antioxidant capacity. Contrarily, during lactation, earlier HT supplementation upregulated antioxidant capacity and modulated antioxidant gene expression (p < 0.05). In calves, there was an increase in SOD1, CAT, and GPX1, especially in the T60%-HT group (p < 0.05). Interestingly, HT supplementation increased glucose transport (SLC2A1/GLUT1) during pregnancy and lactation (p < 0.05). However, it caused different effects on immunometabolic regulation in both dams and calves, depending on maternal diet. Overall, maternal HT supplementation under restricted nutritional conditions promoted postpartum antioxidant capacity and modulated immune and metabolic gene expression in cows and calves.
000164111 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A25-23R$$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2020-113617RR-C22
000164111 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000164111 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164111 700__ $$0(orcid)0000-0001-6445-849X$$aÁlvarez-Rodríguez, Javier$$uUniversidad de Zaragoza
000164111 700__ $$aLópez de Armentia, Leire
000164111 700__ $$aMacià, Alba
000164111 700__ $$aMartín-Alonso, Maria José
000164111 700__ $$aMolina, Ester
000164111 700__ $$aVillalba, Daniel
000164111 700__ $$0(orcid)0000-0002-8122-0069$$aSanz, Albina
000164111 700__ $$aSerrano-Pérez, Beatriz
000164111 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000164111 773__ $$g14, 9 (2025), 1097 [25 pp.]$$pAntioxidants$$tAntioxidants$$x2076-3921
000164111 8564_ $$s3133148$$uhttps://zaguan.unizar.es/record/164111/files/texto_completo.pdf$$yVersión publicada
000164111 8564_ $$s2661892$$uhttps://zaguan.unizar.es/record/164111/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164111 909CO $$ooai:zaguan.unizar.es:164111$$particulos$$pdriver
000164111 951__ $$a2025-11-21-14:26:44
000164111 980__ $$aARTICLE