000164113 001__ 164113
000164113 005__ 20251121161351.0
000164113 0247_ $$2doi$$a10.1007/s11259-025-10970-y
000164113 0248_ $$2sideral$$a146287
000164113 037__ $$aART-2025-146287
000164113 041__ $$aeng
000164113 100__ $$aGiner, Jacobo
000164113 245__ $$aAcute pancreatic panniculitis in a domestic ferret (Mustela putorius furo): diagnostic insights and a potential drug-induced etiology
000164113 260__ $$c2025
000164113 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164113 5203_ $$aPanniculitis is a rare condition in ferrets (Mustela putorius furo), previously linked to nutritional deficiencies, infections, trauma, and injections. Pancreatic panniculitis, caused by the systemic release of pancreatic enzymes during pancreatic injury, has been documented in humans and other animal species, but not in ferrets. This report describes the first known case in a domestic ferret. A 2-year-old male ferret presented with ulcerated cutaneous nodules predominantly affecting the hind limbs and inguinal abdominal region. The ferret had been treated with rifampicin and clarithromycin for suspected mycobacterial infection. Hyperglycemia, hyperglobulinemia, and elevated alkaline phosphatase were noted. Cytology and culture of the lesions revealed neutrophilic inflammation and Pseudomonas aeruginosa, respectively. The animal developed acute abdominal discomfort and died shortly after. Post-mortem examination revealed severe pancreatic necrosis and peripancreatic panniculitis, with splenic pyogranulomatous inflammation. Immunohistochemistry detected systemic coronavirus antigen (clone FCV3-70) only in the spleen. In this patient, prolonged use of rifampicin and clarithromycin is considered a potential contributing factor to the development of acute pancreatic necrosis. This case highlights the clinical relevance of pancreatic panniculitis in ferrets and suggests a possible association between extended rifampicin/clarithromycin therapy and pancreatic necrosis. Ultrasonography and serum glucose, lipase, and amylase measurements are recommended for early diagnosis. Histopathological evaluation remains essential for confirmation.
000164113 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000164113 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164113 700__ $$aVillora, José
000164113 700__ $$aJuan-Sallés, Carles
000164113 700__ $$0(orcid)0000-0002-2685-1730$$aRodriguez-Largo, Ana
000164113 700__ $$0(orcid)0000-0002-9723-9004$$aGómez, Álex$$uUniversidad de Zaragoza
000164113 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000164113 700__ $$aMarteles, Diana$$uUniversidad de Zaragoza
000164113 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000164113 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000164113 773__ $$g50, 1 (2025), [6 PP.]$$pVet. res. commun.$$tVeterinary Research Communications$$x0165-7380
000164113 8564_ $$s1834236$$uhttps://zaguan.unizar.es/record/164113/files/texto_completo.pdf$$yVersión publicada
000164113 8564_ $$s2196934$$uhttps://zaguan.unizar.es/record/164113/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164113 909CO $$ooai:zaguan.unizar.es:164113$$particulos$$pdriver
000164113 951__ $$a2025-11-21-14:26:46
000164113 980__ $$aARTICLE