000164125 001__ 164125
000164125 005__ 20251121161351.0
000164125 0247_ $$2doi$$a10.3390/medicina61091681
000164125 0248_ $$2sideral$$a146279
000164125 037__ $$aART-2025-146279
000164125 041__ $$aeng
000164125 100__ $$0(orcid)0000-0002-4476-6003$$aBartol-Puyal, Francisco de Asís$$uUniversidad de Zaragoza
000164125 245__ $$aRetinal and Choroidal Morphological Features Influencing Contrast Sensitivity in Retinitis Pigmentosa
000164125 260__ $$c2025
000164125 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164125 5203_ $$aBackground and Objectives: To find morphological features on optical coherence tomography (OCT) and OCT-angiography (OCTA) influencing contrast sensitivity (CS) in patients with retinitis pigmentosa (RP). Materials and Methods: Cross-sectional study enrolling 18 eyes of 18 patients with RP. They were examined with CSV1000-E (VectorVision) under mesopic conditions (logarithmic scale), spectral-domain OCT (SD-OCT, Spectralis), swept-source OCT (SS-OCT, Triton), and OCTA (Triton). Automatic thickness measurements of every retinal layer were obtained in grids of 8 × 8 and 10 × 10 cubes. Foveal avascular zone and vascular densities (VD) were also analyzed. Statistical analysis included multiple lineal regression analyses, and a correlation analysis between age, axial length, and intraocular pressure, and retinal nerve fiber layer (RNFL) thickness. Results: Mean age was 47.34 ± 13.77 years. Mean CS with 3, 6, 12, and 18 cycles/degree (c/d) was 1.48 ± 0.37, 1.51 ± 0.39, 1.00 ± 0.42, and 0.44 ± 0.39, respectively. The most related variables to 3 c/d frequency were nasal RFNL thickness (R2 = 0.54) and central outer plexiform layer (OPL) (R2 = 0.33). In case of 6 c/d frequency, it was central VD in deep plexus (R2 = 0.66), and retinal pigment epithelium (RPE) (R2 = 0.22). As for 12 c/d frequency, it was central RNFL (R2 = 0.50), and central VD in deep plexus (R2 = 0.26). Regarding 18 c/d frequency, it was central RNFL (R2 = 0.70). Conclusions: Central and nasal RNFL thickness seem to be main predictors of CS in patients with RP, as well as VD in deep retinal plexus. Others with limited influence might be central and nasal OPL thickness, and central RPE thickness.
000164125 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000164125 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164125 700__ $$aCordón Ciordia, Beatriz$$uUniversidad de Zaragoza
000164125 700__ $$0(orcid)0000-0001-9411-5834$$aViladés Palomar, Elisa$$uUniversidad de Zaragoza
000164125 700__ $$aSantana Plata, Carlos
000164125 700__ $$0(orcid)0000-0001-6072-1545$$aMéndez-Martínez, Silvia$$uUniversidad de Zaragoza
000164125 700__ $$0(orcid)0000-0003-2389-8282$$aPablo Júlvez, Luis$$uUniversidad de Zaragoza
000164125 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000164125 773__ $$g61, 9 (2025), 1681 [10 pp.]$$pMedicina-LithuaniaMedicina (Kaunas)$$tMedicina (Lithuania)$$x1010-660X
000164125 8564_ $$s494993$$uhttps://zaguan.unizar.es/record/164125/files/texto_completo.pdf$$yVersión publicada
000164125 8564_ $$s2633768$$uhttps://zaguan.unizar.es/record/164125/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164125 909CO $$ooai:zaguan.unizar.es:164125$$particulos$$pdriver
000164125 951__ $$a2025-11-21-14:27:01
000164125 980__ $$aARTICLE