000164128 001__ 164128
000164128 005__ 20251121161351.0
000164128 0247_ $$2doi$$a10.1016/j.fpsl.2025.101658
000164128 0248_ $$2sideral$$a146288
000164128 037__ $$aART-2025-146288
000164128 041__ $$aeng
000164128 100__ $$0(orcid)0000-0003-2638-9221$$aCanellas, Elena$$uUniversidad de Zaragoza
000164128 245__ $$aBeyond direct contact: Chemical migration from external printed components of tea packaging into infusions assessed by UPLC-IM-QTOF analysis
000164128 260__ $$c2025
000164128 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164128 5203_ $$aThe safety of food packaging has traditionally focused on materials in direct contact with food, often neglecting the potential contribution of printed external components. This study investigates the migration of chemical substances from non-food-contact elements of tea bag packaging—such as printed labels and external wrappers—into tea infusions prepared under realistic conditions. Migration was simulated by immersing both tea bags and their associated printed materials in boiling water. Extracts were analyzed using ultra-performance liquid chromatography coupled with ion mobility–quadrupole time-of-flight mass spectrometry (UPLC-IM-QTOF), enabling sensitive and multidimensional profiling of known and unknown migrants. Concentrations of identified substances ranged from 5.7 to 369 ng/g, with compound-specific detection limits spanning 1.1–12.3 ng/g. Principal Component Analysis (PCA) revealed that ink and varnish formulations contributed significantly to the variation in migration profiles among brands, despite identical tea compositions. Compounds such as hexadecyl methacrylate and benzophenone were uniquely associated with specific packaging types, while ubiquitous substances like acetyl tributyl citrate and erucamide indicated common ink usage. Notably, several potential endocrine disruptors were detected, although all migration levels remained below current regulatory limits. These results emphasize the importance of including all packaging layers in safety assessments and demonstrate the utility of UPLC-IM-QTOF for comprehensive non-targeted migration analysis.
000164128 536__ $$9info:eu-repo/grantAgreement/ES/MCIN/RYC2021-034150-I$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-123742OB-I00
000164128 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000164128 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164128 700__ $$0(orcid)0000-0003-2685-5739$$aNerin, Cristina$$uUniversidad de Zaragoza
000164128 700__ $$0(orcid)0000-0002-8765-4319$$aVera, Paula$$uUniversidad de Zaragoza
000164128 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000164128 773__ $$g52 (2025), 101658 [7 pp.]$$tFood Packaging and Shelf Life$$x2214-2894
000164128 8564_ $$s1492453$$uhttps://zaguan.unizar.es/record/164128/files/texto_completo.pdf$$yVersión publicada
000164128 8564_ $$s2502746$$uhttps://zaguan.unizar.es/record/164128/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164128 909CO $$ooai:zaguan.unizar.es:164128$$particulos$$pdriver
000164128 951__ $$a2025-11-21-14:27:04
000164128 980__ $$aARTICLE