000164137 001__ 164137
000164137 005__ 20251121161352.0
000164137 0247_ $$2doi$$a10.1111/phpp.70062
000164137 0248_ $$2sideral$$a146304
000164137 037__ $$aART-2025-146304
000164137 041__ $$aeng
000164137 100__ $$aKrutmann, Jean
000164137 245__ $$aPINGing Sunshine: A Review of the Evidence for Adding Non-Filtering Photoprotective Ingredients to Sunscreens
000164137 260__ $$c2025
000164137 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164137 5203_ $$aBackground: Photoprotective INGredients (PINGs) are non-filtering agents that enhance the skin's intrinsic defenses against solar radiation. Acting through antioxidant, DNA repair, immunomodulatory, anti-inflammatory, and pigmentation-regulating
mechanisms, PINGs may prevent or repair photodamage. When incorporated into sunscreens, they offer protection beyond ultraviolet (UV) filters. This strategy of biological photoprotection could address key limitations of traditional sunscreens and
reduce dependence on high UV filter concentrations.
Methods: We conducted a focused literature review based on our prior evidence-based classification of over 1700 topical PINGs. We selected ingredients with the strongest clinical and mechanistic support and assessed their biological activity, formulation compatibility, and relevance to key endpoints such as erythema, pigmentation, photoaging, and immunosuppression.
Results: Top-ranked PINGs, including L-ascorbic acid, tocopherol, photolyase, and nicotinamide, demonstrated efficacy across multiple photodamage endpoints. Antioxidants like L-ascorbic acid and tocopherol enhanced protection against UVR and IR-A-
induced oxidative stress. DNA repair enzymes, such as photolyase, reduced cyclobutane pyrimidine dimer formation and supported immune function. Nicotinamide improved DNA repair and prevented UV-induced immunosuppression. Pigmentation modulators such as p-coumaric acid and isobutylamido thiazolyl resorcinol showed benefits in darker phototypes.
Conclusions: Fewer than 2% of candidate PINGs are clinically validated, and only 18 are approved for use in sunscreens. Protection against visible and infrared radiation remains largely underexplored. Standardized testing and additional clinical
trials are needed to advance PINGs as effective components of next-generation sunscreens.
000164137 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000164137 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164137 700__ $$aBrown, Anthony
000164137 700__ $$aPasseron, Thierry
000164137 700__ $$aGranger, Corinne
000164137 700__ $$0(orcid)0000-0001-8034-3617$$aGilaberte, Yolanda$$uUniversidad de Zaragoza
000164137 700__ $$aTrullas, Carles
000164137 700__ $$aPiquero-Casals, Jaime
000164137 700__ $$aLeone, Giovanni
000164137 700__ $$aSchalka, Sergio
000164137 700__ $$aLim, Henry W.
000164137 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000164137 773__ $$g41, 6 (2025), e70062 [25 pp.]$$pPhotodermatol. photoimmunol. photomed.$$tPHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE$$x0905-4383
000164137 8564_ $$s711147$$uhttps://zaguan.unizar.es/record/164137/files/texto_completo.pdf$$yVersión publicada
000164137 8564_ $$s2569826$$uhttps://zaguan.unizar.es/record/164137/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164137 909CO $$ooai:zaguan.unizar.es:164137$$particulos$$pdriver
000164137 951__ $$a2025-11-21-14:27:15
000164137 980__ $$aARTICLE