000164140 001__ 164140
000164140 005__ 20251121161352.0
000164140 0247_ $$2doi$$a10.1016/j.colsurfb.2025.115235
000164140 0248_ $$2sideral$$a146313
000164140 037__ $$aART-2025-146313
000164140 041__ $$aeng
000164140 100__ $$aCanalejo-Marco, Gonzalo
000164140 245__ $$aUnlocking the potential of bacterial membrane vesicles: Advances in isolation techniques and biomedical applications
000164140 260__ $$c2025
000164140 5060_ $$aAccess copy available to the general public$$fUnrestricted
000164140 5203_ $$aBacterial membrane vesicles (MVs) are nanosized, lipid bilayer-enclosed structures released by both Gram-positive (commonly referred as MVS, bacterial membrane vesicles) and Gram-negative bacteria (commonly referred as OMVs, outer membrane vesicles and outer-inner membrane vesicles (OIMVs)). They carry proteins, lipids, nucleic acids, and metabolites, playing key roles in intercellular communication, host–pathogen interactions, and immune modulation. Owing to these properties, MVs are attracting growing interest as versatile tools for vaccine development, drug delivery, and diagnostic applications. However, their translation remains constrained by low production yields, potential toxicity, and the lack of standardized isolation and characterization methods. This review summarizes current knowledge on MV composition and biogenesis, with a particular focus on emerging strategies for their isolation and engineering, and highlights their biomedical potential while outlining the challenges that must be overcome to enable future clinical applications.
000164140 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127847OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-146091OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2024–160339OB-I00$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S
000164140 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000164140 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000164140 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000164140 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000164140 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000164140 773__ $$g258 (2025), 115235 [18 pp.]$$pColloids surf., B Biointerfaces$$tCOLLOIDS AND SURFACES B-BIOINTERFACES$$x0927-7765
000164140 8564_ $$s8630653$$uhttps://zaguan.unizar.es/record/164140/files/texto_completo.pdf$$yVersión publicada
000164140 8564_ $$s2665650$$uhttps://zaguan.unizar.es/record/164140/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000164140 909CO $$ooai:zaguan.unizar.es:164140$$particulos$$pdriver
000164140 951__ $$a2025-11-21-14:27:19
000164140 980__ $$aARTICLE