164211 20251127172931.0 doi 10.1002/smsc.202500351 sideral 146411 ART-2025-146411 eng Marcuello, Carlos Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration 2025 Nanobiomedicine promises to revolutionize life quality and expectancy of patients with cognitive impairment and cancer malignancies, via unraveling key molecular processes related to their onset useful as biomarkers of disease to develop and improve the efficacy of therapies. However, it is still a challenge understanding and identifying these molecular mechanisms as biomarkers of disease, because of their high‐level of polymorphism and nanoscale dimensions. Here, it provides a review work linking the potential and capabilities of atomic force microscopy (AFM) technologies in unraveling beyond imaging the common and hidden properties of transient and nanosized molecular processes in cancer and neurodegeneration. This study highlights the most prominent operational modes of AFM to achieve morphological, mechanical, and chemical characterization of the molecular processes leading to these diseases. Finally, it outlines the advantages of AFM compared with other techniques to guide newcomers and stakeholders toward potential future avenues opened by AFM methods in nanobiomedicine. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lim, KeeSiang Nisini, Giacomo Pokrovsky, Vadim S. Conde, João Ruggeri, Francesco Simone 5, 11 (2025), 45 pp. Small Science 2688-4046 14874652 http://zaguan.unizar.es/record/164211/files/texto_completo.pdf Versión publicada 2277802 http://zaguan.unizar.es/record/164211/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:164211 articulos driver 2025-11-27-15:17:10 ARTICLE