165115 20251212165958.0 doi 10.3390/ph18121845 sideral 146609 ART-2025-146609 eng Avedillo-Salas, Ana Universidad de Zaragoza (orcid)0000-0003-2153-0417 Prescribed Drugs and Interpersonal Violence: A Case–Non-Case Study in the Spanish Pharmacovigilance Database 2025 Background/Objectives: Interpersonal violence is an increasing public health concern, and its prediction and prevention remain global challenges. This study aimed to identify prescribed medications associated with interpersonal violence in Spain. Methods: A descriptive, longitudinal and retrospective study and case-non case study of spontaneous reports of adverse drug reactions corresponding to interpersonal violence recorded in the Spanish Pharmacovigilance Database (FEDRA®) from 1984 to 31 March 2021. Results: 533 cases were reported in the study period. The mean age was 46.70 years with ages ranging from 1 to 99 years. There were no sex differences except in child and adolescent age group where most reports were from male. Main therapeutic groups involved were nervous system (62.3%), anti-infectives for systemic use (10%) and respiratory system (8.6%). Mostly drugs reported were montelukast, levetiracetam, bupropion, donepezil, perampanel, quetiapine, fluoxetine, and lorazepam. A statistically significant association/disproportion in the notification has been found in the reporting of interpersonal violence and different drugs according to the literature, notably atomoxetine, perampanel, memantine, donepezil, montelukast and methylphenidate. Conclusions: The results highlight that interpersonal violence, while rare, could occur as a clinically relevant adverse reaction to a small subset of medications. They underscore the importance of careful prescribing, especially in vulnerable populations and in individuals with a history of psychiatric disorders. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fanlo-Villacampa, Ana Universidad de Zaragoza (orcid)0000-0001-8064-8138 Lanuza-Giménez, Francisco Javier Universidad de Zaragoza (orcid)0000-0002-6485-1926 Vicente-Romero, Jorge Universidad de Zaragoza (orcid)0000-0003-4629-6743 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 18, 12 (2025), 1845 [19 pp.] Pharmaceuticals Pharmaceuticals 1424-8247 1184982 http://zaguan.unizar.es/record/165115/files/texto_completo.pdf Versión publicada 2610347 http://zaguan.unizar.es/record/165115/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165115 articulos driver 2025-12-12-14:42:58 ARTICLE