000165128 001__ 165128
000165128 005__ 20251212165958.0
000165128 0247_ $$2doi$$a10.1002/ijc.70256
000165128 0248_ $$2sideral$$a146616
000165128 037__ $$aART-2025-146616
000165128 041__ $$aeng
000165128 100__ $$aBlanco-Lopez, Jessica
000165128 245__ $$aRole of the perinatal experience on the risk of acute leukemia in childhood or adolescence: Systematic review and meta‐analysis
000165128 260__ $$c2025
000165128 5203_ $$aAcute leukemia is the most common type of cancer in children; however, the etiology is poorly understood. The objective of this review was to summarize the current evidence of the role of perinatal factors in the development of acute leukemia. All epidemiological studies published up to October 2023 that evaluated perinatal risk factors for childhood acute leukemia were identified using a multi‐tiered approach in two electronic databases (PubMed and Web of Science), without restriction on publication year or language. A total of 85 studies (13 prospective cohort studies, 62 case–control studies, and 10 pooled analyses) were included. We combined the published risk estimates in a meta‐analysis, using the Generic Inverse Variance method. An increased risk of acute leukemia and the lymphoblastic subtype (ALL) was associated with high birth weight (>4000 g) (odds ratio [OR] = 1.35; 95% confidence interval [95% CI] 1.20–1.53 and OR = 1.21; 95% CI 1.08–1.34, respectively), maternal history of abortion (OR = 1.27; 95% CI 1.12–1.43 and OR = 1.24; 95% CI 1.08–1.43, respectively), and maternal diabetes (OR = 1.30; 95% CI 1.14–1.48 and OR = 1.32; 95% CI 1.16–1.50, respectively). In addition, an increased risk for ALL was also associated with maternal hypertension (OR = 1.21; 95% CI 1.06–1.38) and cesarean section (OR = 1.10; 95% CI 1.05–1.16). Our review suggests a potential role for perinatal factors in the development of acute leukemia in children. These findings indicate potential avenues for developing cost‐effective prevention strategies applicable at the population level, while the mechanism of action is investigated.
000165128 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165128 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165128 700__ $$aKintossou, Ambroise Kouame
000165128 700__ $$aManohar, Shiny
000165128 700__ $$0(orcid)0000-0003-4242-5464$$aIguacel, Isabel$$uUniversidad de Zaragoza
000165128 700__ $$aPisanu, Silvia
000165128 700__ $$aAlmeida, Claudia Choma Bettega
000165128 700__ $$aSteliarova-Foucher, Eva
000165128 700__ $$aSierens, Ciska
000165128 700__ $$aGunter, Marc J.
000165128 700__ $$aLadas, Elena J.
000165128 700__ $$aBarr, Ronald D.
000165128 700__ $$aVan Herck, Koen
000165128 700__ $$aKozlakidis, Zisis
000165128 700__ $$aHuybrechts, Inge
000165128 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000165128 773__ $$g(2025), [26 pp.]$$pInt. j. cancer$$tINTERNATIONAL JOURNAL OF CANCER$$x0020-7136
000165128 8564_ $$s11840973$$uhttps://zaguan.unizar.es/record/165128/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-11-07
000165128 8564_ $$s2248254$$uhttps://zaguan.unizar.es/record/165128/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-11-07
000165128 909CO $$ooai:zaguan.unizar.es:165128$$particulos$$pdriver
000165128 951__ $$a2025-12-12-14:43:14
000165128 980__ $$aARTICLE