000165169 001__ 165169
000165169 005__ 20251219174251.0
000165169 0247_ $$2doi$$a10.1016/j.etap.2025.104874
000165169 0248_ $$2sideral$$a146717
000165169 037__ $$aART-2025-146717
000165169 041__ $$aeng
000165169 100__ $$aRuiz-Sobremazas, Diego$$uUniversidad de Zaragoza
000165169 245__ $$aLong-term impact of oral gestational PM10 exposure on morris water maze performance and hippocampal gene expression
000165169 260__ $$c2025
000165169 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165169 5203_ $$aEnvironmental exposure to air pollution, specially to particulate matter (PM) during pregnancy, plays a significant role in increasing the risk of neurodevelopmental disorders such as autism. This study investigated the long-term impact of oral gestational PM exposure (200 µg/kg/day) on memory in aged rats using the Morris Water Maze (MWM). After completing MWM, hippocampal tissue was collected and analyzed for gene expression. Our findings indicate that gestational PM exposure caused no major developmental alterations, aside from slightly poorer performance in the adherence test. No differences were detected in standard MWM manipulations, however, PM-offspring showed reduced latency in the test session, suggesting a possible compulsive-like behavior. Additionally, hippocampal gene expression revealed downregulation of several genes, including NMDA and GABAergic subunits. These effects depended on exposure and sex. The behavioral effects might reflect cognitive inflexibility linked to gene alterations. Further research is needed to clarify these outcomes.
000165169 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C31/AEI/10.13039/501100011033$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C32/AEI/10.13039/501100011033$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C33/AEI/10.13039/501100011033
000165169 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000165169 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165169 700__ $$aCoca, Mario
000165169 700__ $$aMorales-Navas, Miguel
000165169 700__ $$aRios Nieto, Nerea
000165169 700__ $$aRodulfo-Cárdenas, Rocío
000165169 700__ $$aColomina, Maria Teresa
000165169 700__ $$0(orcid)0000-0001-6767-8252$$aLópez-Granero, Caridad$$uUniversidad de Zaragoza
000165169 700__ $$aSanchez-Santed, Fernando
000165169 700__ $$aPérez-Fernández, Cristian
000165169 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000165169 773__ $$g120 (2025), 104874 [16 pp.]$$pEnviron. toxicol. pharmacol.$$tENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY$$x1382-6689
000165169 8564_ $$s11151740$$uhttps://zaguan.unizar.es/record/165169/files/texto_completo.pdf$$yVersión publicada
000165169 8564_ $$s2638681$$uhttps://zaguan.unizar.es/record/165169/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165169 909CO $$ooai:zaguan.unizar.es:165169$$particulos$$pdriver
000165169 951__ $$a2025-12-19-14:42:16
000165169 980__ $$aARTICLE