165169 20251219174251.0 doi 10.1016/j.etap.2025.104874 sideral 146717 ART-2025-146717 eng Ruiz-Sobremazas, Diego Universidad de Zaragoza Long-term impact of oral gestational PM10 exposure on morris water maze performance and hippocampal gene expression 2025 Environmental exposure to air pollution, specially to particulate matter (PM) during pregnancy, plays a significant role in increasing the risk of neurodevelopmental disorders such as autism. This study investigated the long-term impact of oral gestational PM exposure (200 µg/kg/day) on memory in aged rats using the Morris Water Maze (MWM). After completing MWM, hippocampal tissue was collected and analyzed for gene expression. Our findings indicate that gestational PM exposure caused no major developmental alterations, aside from slightly poorer performance in the adherence test. No differences were detected in standard MWM manipulations, however, PM-offspring showed reduced latency in the test session, suggesting a possible compulsive-like behavior. Additionally, hippocampal gene expression revealed downregulation of several genes, including NMDA and GABAergic subunits. These effects depended on exposure and sex. The behavioral effects might reflect cognitive inflexibility linked to gene alterations. Further research is needed to clarify these outcomes. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C31/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C32/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C33/AEI/10.13039/501100011033 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Coca, Mario Morales-Navas, Miguel Rios Nieto, Nerea Rodulfo-Cárdenas, Rocío Colomina, Maria Teresa López-Granero, Caridad Universidad de Zaragoza (orcid)0000-0001-6767-8252 Sanchez-Santed, Fernando Pérez-Fernández, Cristian 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 120 (2025), 104874 [16 pp.] Environ. toxicol. pharmacol. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 1382-6689 11151740 http://zaguan.unizar.es/record/165169/files/texto_completo.pdf Versión publicada 2638681 http://zaguan.unizar.es/record/165169/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165169 articulos driver 2025-12-19-14:42:16 ARTICLE