000165176 001__ 165176
000165176 005__ 20251219174251.0
000165176 0247_ $$2doi$$a10.1016/j.impact.2025.100600
000165176 0248_ $$2sideral$$a146736
000165176 037__ $$aART-2025-146736
000165176 041__ $$aeng
000165176 100__ $$0(orcid)0000-0003-2936-242X$$aCatalán, Julia$$uUniversidad de Zaragoza
000165176 245__ $$aAn integrated approach to assess exposure and early health effects in human populations exposed to micro- and nanoplastics
000165176 260__ $$c2025
000165176 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165176 5203_ $$aAlthough cumulative evidence from in vitro and in vivo studies indicates that micro- and nanoplastics (MNPs) can induce toxic effects, and MNPs have been detected in several human fluids and tissues, the consequences of MNP exposure to human health still remain unknown. Human biomonitoring (HBM) studies allow assessing human exposure to MPs and associated adverse health effects, contributing to the risk assessment of these environmental pollutants. To date, reliable human exposure estimates are hindered by the lack of standardized processing and analytical methods to detect MNPs in human tissues, and limited evidence on the MNP-related adverse health effects exists. Occupational environments, where plastics are processed, may represent prioritized settings for such evaluations, as workers typically face higher exposure levels than the general population. Population sub-groups with potentially higher susceptibility, such as children and pregnant women, should also be considered. To develop effective preventive strategies, it is essential to identify and validate sensitive and specific biomarkers of exposure and early biological changes, which could result in adverse health effects. Standardized protocols integrating environmental exposure assessment with HBM, and sensitive methods for evaluating internal dose resulting from cumulative exposure to MNP particles and associated chemicals are needed. Based on the experience gathered by a multidisciplinary panel of experts belonging to the European Research Cluster to Understand the Health Impacts of MNPs (CUSP), this consensus paper describes the key elements that should be part of an integrated HBM approach for MNP exposure, emphasizing existing challenges and proposing solutions for future studies.
000165176 536__ $$9info:eu-repo/grantAgreement/EC/H2020/964766/EU/Understanding human exposure and health hazard of micro- and nanoplastic contaminants in our environment/POLYRISK$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 964766-POLYRISK$$9info:eu-repo/grantAgreement/EC/H2020/964827/EU/Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics/AURORA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 964827-AURORA$$9info:eu-repo/grantAgreement/EC/H2020/965173/EU/AN INNOVATIVE ANALYTICAL PLATFORM TO INVESTIGATE THE EFFECT AND TOXICITY OF MICRO AND NANO PLASTICS COMBINED WITH ENVIRONMENTAL CONTAMINANTS ON THE RISK OF ALLERGIC DISEASE IN PRECLINICAL AND CLINICAL/IMPTOX$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965173-IMPTOX$$9info:eu-repo/grantAgreement/EC/H2020/965196/EU/Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment/PLASTICHEAL$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965196-PLASTICHEAL$$9info:eu-repo/grantAgreement/EC/H2020/965367/EU/Plastics fate and effects in the human body/PlasticsFatE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965367-PlasticsFatE
000165176 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000165176 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165176 700__ $$aAfanou, Anani K.
000165176 700__ $$aArranz, Jéssica Arribas
000165176 700__ $$aRiaza, Arantxa Ballesteros
000165176 700__ $$aBanic, Ivana
000165176 700__ $$aDirven, Hubert
000165176 700__ $$aEstrela-Lopis, Irina
000165176 700__ $$aHernández, Alba
000165176 700__ $$aKanerva, Tomi
000165176 700__ $$aLaforsch, Christian
000165176 700__ $$aLenssen, Esther
000165176 700__ $$aLöder, Martin G.J.
000165176 700__ $$aPastor, Susana
000165176 700__ $$aPulli, Hanna
000165176 700__ $$aRamsperger, Anja F.R.M.
000165176 700__ $$aSnapkow, Igor
000165176 700__ $$aTurkalj, Mirjana
000165176 700__ $$aVela, Verónica
000165176 700__ $$aVenus, Tom
000165176 700__ $$aZou, Runyu
000165176 700__ $$aBergamaschi, Enrico
000165176 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000165176 773__ $$g40 (2025), 100600 [14 pp.]$$tNanoImpact$$x2452-0748
000165176 8564_ $$s4884283$$uhttps://zaguan.unizar.es/record/165176/files/texto_completo.pdf$$yVersión publicada
000165176 8564_ $$s2388106$$uhttps://zaguan.unizar.es/record/165176/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165176 909CO $$ooai:zaguan.unizar.es:165176$$particulos$$pdriver
000165176 951__ $$a2025-12-19-14:42:26
000165176 980__ $$aARTICLE