000165190 001__ 165190
000165190 005__ 20251219174251.0
000165190 0247_ $$2doi$$a10.1128/MCB.00025-10
000165190 0248_ $$2sideral$$a72014
000165190 037__ $$aART-2010-72014
000165190 041__ $$aeng
000165190 100__ $$aPerales-Clemente, E.
000165190 245__ $$aFive entry points of the mitochondrially encoded subunits in mammalian complex I assembly
000165190 260__ $$c2010
000165190 5203_ $$aComplex I (CI) is the largest enzyme of the mammalian mitochondrial respiratory chain. The biogenesis of the complex is a very complex process due to its large size and number of subunits (45 subunits). The situation is further complicated due to the fact that its subunits have a double genomic origin, as seven of them are encoded by the mitochondrial DNA. Understanding of the assembly process and characterization of the involved factors has advanced very much in the last years. However, until now, a key part of the process, that is, how and at which step the mitochondrially encoded CI subunits (ND subunits) are incorporated in the CI assembly process, was not known. Analyses of several mouse cell lines mutated for three ND subunits allowed us to determine the importance of each one for complex assembly/stability and that there are five different steps within the assembly pathway in which some mitochondrially encoded CI subunit is incorporated.
000165190 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165190 590__ $$a6.188$$b2010
000165190 591__ $$aCELL BIOLOGY$$b39 / 175 = 0.223$$c2010$$dQ1$$eT1
000165190 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b41 / 284 = 0.144$$c2010$$dQ1$$eT1
000165190 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165190 700__ $$0(orcid)0000-0002-2469-142X$$aFernandez-Vizarra, E.$$uUniversidad de Zaragoza
000165190 700__ $$aAcin-Perez, R.
000165190 700__ $$0(orcid)0000-0002-0163-8378$$aMovilla, N.$$uUniversidad de Zaragoza
000165190 700__ $$0(orcid)0000-0002-8585-6371$$aBayona-Bafaluy, M. P.$$uUniversidad de Zaragoza
000165190 700__ $$0(orcid)0000-0002-6600-1618$$aMoreno-Loshuertos, R.$$uUniversidad de Zaragoza
000165190 700__ $$0(orcid)0000-0002-8705-2799$$aPerez-Martos, A.$$uUniversidad de Zaragoza
000165190 700__ $$0(orcid)0000-0001-8971-7355$$aFernandez-Silva, P.$$uUniversidad de Zaragoza
000165190 700__ $$0(orcid)0000-0002-4931-6730$$aEnriquez, J. A.$$uUniversidad de Zaragoza
000165190 7102_ $$11002$$2X$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cProy. investigación DEA
000165190 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000165190 773__ $$g30, 12 (2010), 3038-3047$$pMol. cell. biol.$$tMolecular and cellular biology$$x0270-7306
000165190 8564_ $$s2319539$$uhttps://zaguan.unizar.es/record/165190/files/texto_completo.pdf$$yVersión publicada
000165190 8564_ $$s3459456$$uhttps://zaguan.unizar.es/record/165190/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165190 909CO $$ooai:zaguan.unizar.es:165190$$particulos$$pdriver
000165190 951__ $$a2025-12-19-14:42:44
000165190 980__ $$aARTICLE