165190 20251219174251.0 doi 10.1128/MCB.00025-10 sideral 72014 ART-2010-72014 eng Perales-Clemente, E. Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly 2010 Complex I (CI) is the largest enzyme of the mammalian mitochondrial respiratory chain. The biogenesis of the complex is a very complex process due to its large size and number of subunits (45 subunits). The situation is further complicated due to the fact that its subunits have a double genomic origin, as seven of them are encoded by the mitochondrial DNA. Understanding of the assembly process and characterization of the involved factors has advanced very much in the last years. However, until now, a key part of the process, that is, how and at which step the mitochondrially encoded CI subunits (ND subunits) are incorporated in the CI assembly process, was not known. Analyses of several mouse cell lines mutated for three ND subunits allowed us to determine the importance of each one for complex assembly/stability and that there are five different steps within the assembly pathway in which some mitochondrially encoded CI subunit is incorporated. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.188 2010 CELL BIOLOGY 39 / 175 = 0.223 2010 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 41 / 284 = 0.144 2010 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fernandez-Vizarra, E. Universidad de Zaragoza (orcid)0000-0002-2469-142X Acin-Perez, R. Movilla, N. Universidad de Zaragoza (orcid)0000-0002-0163-8378 Bayona-Bafaluy, M. P. Universidad de Zaragoza (orcid)0000-0002-8585-6371 Moreno-Loshuertos, R. Universidad de Zaragoza (orcid)0000-0002-6600-1618 Perez-Martos, A. Universidad de Zaragoza (orcid)0000-0002-8705-2799 Fernandez-Silva, P. Universidad de Zaragoza (orcid)0000-0001-8971-7355 Enriquez, J. A. Universidad de Zaragoza (orcid)0000-0002-4931-6730 1002 X Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Proy. investigación DEA 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 30, 12 (2010), 3038-3047 Mol. cell. biol. Molecular and cellular biology 0270-7306 2319539 http://zaguan.unizar.es/record/165190/files/texto_completo.pdf Versión publicada 3459456 http://zaguan.unizar.es/record/165190/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165190 articulos driver 2025-12-19-14:42:44 ARTICLE