000165191 001__ 165191
000165191 005__ 20251219174251.0
000165191 0247_ $$2doi$$a10.3390/nu17223512
000165191 0248_ $$2sideral$$a146772
000165191 037__ $$aART-2025-146772
000165191 041__ $$aeng
000165191 100__ $$0(orcid)0000-0002-5407-3876$$aSanclemente, Teresa$$uUniversidad de Zaragoza
000165191 245__ $$aAssessment of CoQ10 dietary intake in a mediterranean cohort of familial hypercholesterolemia patients: a pilot study
000165191 260__ $$c2025
000165191 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165191 5203_ $$aBackground/Objectives: Coenzyme Q 10 is a lipid molecule that works as a mobile electron transporter in the mitochondrial respiratory chain and, in addition, plays the role of an antioxidant. Interestingly, CoQ10 synthesis in human cells derives from the mevalonate pathway, the same metabolic route that delivers endogenous cholesterol. Mutations leading to Familial Hypercholesterolemia (FH) alter the levels of CoQ10 production and remarkably, statin therapy associated muscular symptoms (SAMSs) might also be modulated by CoQ10 supplementation. CoQ10 is also provided by diet and only a few studies have calculated the dietary intake of this metabolite among populations. Methods: Here, we present our Spanish FH cohort (n = 261) and characterized relevant clinical, metabolic, and anthropometric parameters. Results: A cohort of 75.1% followed lipid-lowering treatment at inclusion, being the most prescribed drugs statin alone (32.7%) and statins combined with ezetimibe (56.6%). The average time on statin treatment was 3.7 years. Interestingly, 22% of cohort patients presented with SAMS. In addition, we performed an exhaustive literature review to define for the first time the CoQ10 content present in food typically found in Spain or other southern-European countries and classified them from very rich (over 50 mg/kg) to very poor (<1 mg/kg). With this information, we calculated the daily intake of CoQ10 from a small group (12) of selected FH patients using a validated food-frequency questionnaire (FFQ) and determined a daily intake 9.72 ± 2.64 mg/day, different to other described populations. Conclusions: we discussed the relevance of exogenous CoQ10 for FH development and potential SAMS. Interestingly, this information can be extrapolated to define the regular CoQ10 intake of the Spanish population, especially when following the MedDiet.
000165191 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029544-I
000165191 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000165191 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165191 700__ $$aCarazo, Alicia
000165191 700__ $$aSilvestre-Muñoz, Tania
000165191 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, Julio$$uUniversidad de Zaragoza
000165191 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, Eduardo$$uUniversidad de Zaragoza
000165191 700__ $$0(orcid)0000-0002-1309-4363$$aPuzo, José$$uUniversidad de Zaragoza
000165191 700__ $$0(orcid)0000-0003-2645-3983$$aPacheu-Grau, David$$uUniversidad de Zaragoza
000165191 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000165191 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000165191 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000165191 773__ $$g17, 22 (2025), 3512 [22 pp.]$$pNutrients$$tNutrients$$x2072-6643
000165191 8564_ $$s340430$$uhttps://zaguan.unizar.es/record/165191/files/texto_completo.pdf$$yVersión publicada
000165191 8564_ $$s2461895$$uhttps://zaguan.unizar.es/record/165191/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165191 909CO $$ooai:zaguan.unizar.es:165191$$particulos$$pdriver
000165191 951__ $$a2025-12-19-14:42:45
000165191 980__ $$aARTICLE