165209 20251219174251.0 doi 10.1016/j.mito.2010.09.011 sideral 72704 ART-2011-72704 eng Fernández-Vizarra, E. (orcid)0000-0002-2469-142X Tissue-specific differences in mitochondrial activity and biogenesis 2011 Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number, function, protein composition and morphology. The OXPHOS system biogenesis requires the coordinated expression of both mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be regulated at different levels (replication, transcription, translation and post-translational levels) to contribute to the final observed OXPHOS activities. By analyzing five mammalian tissues, we evaluated the differences in the cellular amount of mtDNA and its correlation with the final observed mitochondrial activity. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.615 2011 GENETICS & HEREDITY 45 / 156 = 0.288 2011 Q2 T1 CELL BIOLOGY 78 / 179 = 0.436 2011 Q2 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Enríquez, J. A. Universidad de Zaragoza (orcid)0000-0002-4931-6730 Pérez-Martos, A. Universidad de Zaragoza (orcid)0000-0002-8705-2799 Montoya, J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Fernández-Silva, P. Universidad de Zaragoza (orcid)0000-0001-8971-7355 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 11, 1 (2011), 207-213 Mitochondrion MITOCHONDRION 1567-7249 1344739 http://zaguan.unizar.es/record/165209/files/texto_completo.pdf Versión publicada 3026167 http://zaguan.unizar.es/record/165209/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165209 articulos driver 2025-12-19-14:43:04 ARTICLE