000165210 001__ 165210
000165210 005__ 20251219174251.0
000165210 0247_ $$2doi$$a10.1007/s00294-008-0194-x
000165210 0248_ $$2sideral$$a64636
000165210 037__ $$aART-2008-64636
000165210 041__ $$aeng
000165210 100__ $$0(orcid)0000-0002-2469-142X$$aFernández-Vizarra, E.$$uUniversidad de Zaragoza
000165210 245__ $$aMitochondrial Gene Expression is Regulated at Multiple Levels and Differentially in the Heart and Liver by Thyroid Hormones
000165210 260__ $$c2008
000165210 5203_ $$aBiogenesis of the oxidative phosphorylation system (OXPHOS) requires the coordinated expression of the nuclear and the mitochondrial genomes. Thyroid hormones play an important role in cell growth and differentiation and are one of the main effectors in mitochondrial biogenesis. To determine how mtDNA expression is regulated, we have investigated the response of two different tissues, the heart and liver, to the thyroid hormone status in vivo and in vitro. We show here that mtDNA expression is a tightly regulated process and that several levels of control can take place simultaneously. In addition, we show that the mechanisms operating in the control of mtDNA expression and their relevance differ between the two tissues, being gene dosage important only in heart while transcription rate and translation efficiency have more weight in liver cells. Another interesting difference is the lack of a direct effect of thyroid hormones on heart mitochondrial transcription.
000165210 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165210 590__ $$a2.323$$b2008
000165210 591__ $$aGENETICS & HEREDITY$$b80 / 135 = 0.593$$c2008$$dQ3$$eT2
000165210 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165210 700__ $$0(orcid)0000-0002-4931-6730$$aEnríquez,J. A.$$uUniversidad de Zaragoza
000165210 700__ $$0(orcid)0000-0002-8705-2799$$aPérez-Martos,A.$$uUniversidad de Zaragoza
000165210 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya,J.$$uUniversidad de Zaragoza
000165210 700__ $$0(orcid)0000-0001-8971-7355$$aFernández-Silva,P.$$uUniversidad de Zaragoza
000165210 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000165210 773__ $$g54, 1 (2008), 13-22$$pCurr. genet.$$tCURRENT GENETICS$$x0172-8083
000165210 8564_ $$s552588$$uhttps://zaguan.unizar.es/record/165210/files/texto_completo.pdf$$yVersión publicada
000165210 8564_ $$s2417424$$uhttps://zaguan.unizar.es/record/165210/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165210 909CO $$ooai:zaguan.unizar.es:165210$$particulos$$pdriver
000165210 951__ $$a2025-12-19-14:43:06
000165210 980__ $$aARTICLE